RT Journal Article
T1 The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity
A1 Lupu, Diana
A1 Andersson, Patrik
A1 Bornehag, Carl-Gustaf
A1 Demeneix, Barbara
A1 Fritsche, Ellen
A1 Gennings, Chris
A1 Lichtensteiger, Walter
A1 Leist, Marcel
A1 Leonards, Pim E. G.
A1 Ponsonby, Anne-Louise
A1 Scholze, Martin
A1 Testa, Giuseppe
A1 Fernández-Tresguerres Hernández, Jesús Ángel
A1 Westerink, Remco H. S.
A1 Zalc, Bernard
A1 Rüegg, Joëlle
AB Ubiquitous exposure to endocrine-disrupting chemicals (EDCs) has caused serious concerns about the ability of these chemicals to affect neurodevelopment, among others. Since endocrine disruption (ED)-induced developmental neurotoxicity (DNT) is hardly covered by the chemical testing tools that are currently in regulatory use, the Horizon 2020 research and innovation action ENDpoiNTs has been launched to fill the scientific and methodological gaps related to the assessment of this type of chemical toxicity. The ENDpoiNTs project will generate new knowledge about ED-induced DNT and aims to develop and improve in vitro, in vivo, and in silico models pertaining to ED-linked DNT outcomes for chemical testing. This will be achieved by establishing correlative and causal links between known and novel neurodevelopmental endpoints and endocrine pathways through integration of molecular, cellular, and organismal data from in vitro and in vivo models. Based on this knowledge, the project aims to provide adverse outcome pathways (AOPs) for ED-induced DNT and to develop and integrate new testing tools with high relevance for human health into European and international regulatory frameworks.
PB MDPI
SN 1422-0067
YR 2020
FD 2020-06-01
LK https://hdl.handle.net/20.500.14352/8198
UL https://hdl.handle.net/20.500.14352/8198
LA eng
NO Unión Europea/Programa Horizonte2020
DS Docta Complutense
RD 6 abr 2025