RT Journal Article
T1 Embolization therapy with microspheres for the treatment of liver cancer: State-of-the-art of clinical translation
A1 Pérez López, Alexandre
A1 Martín Sabroso, Cristina
A1 Gómez Lázaro, Laura
A1 Torres Suárez, Ana Isabel
A1 Aparicio Blanco, Juan
AB Embolization with microspheres is a therapeutic strategy based on the selective occlusion of the blood vessels feeding a tumor. This procedure is intraarterially performed in the clinical setting for the treatment of liver cancer. The practice has evolved over the last decade through the incorporation of drug loading ability, biodegradability and imageability with the subsequent added functionality for the physicians and improved clinical outcomes for the patients. This review highlights the evolution of the embolization systems developed through the analysis of the marketed embolic microspheres for the treatment of malignant hepatocellular carcinoma, namely the most predominant form of liver cancer. Embolic microspheres for the distinct modalities of embolization (i.e., bland embolization, chemoembolization and radioembolization) are here comprehensively compiled with emphasis on material characteristics and their impact on microsphere performance. Moreover, the future application of the embolics under clinical investigation is discussed along with the scientific and regulatory challenges ahead in the field.
PB Elsevier
SN 1742-7061
YR 2022
FD 2022-08-10
LK https://hdl.handle.net/20.500.14352/71893
UL https://hdl.handle.net/20.500.14352/71893
LA eng
NO CRUE-CSIC (Acuerdos Transformativos 2022)
NO Ministerio de Ciencia e Innovación (MICINN)
NO Universidad Complutense de Madrid/Banco de Santander
DS Docta Complutense
RD 3 oct 2024