RT Journal Article T1 A web-enabled, school-based intervention for bullying prevention (LINKlusive): a cluster randomised trial A1 Abregú Crespo, Renzo A1 Huete-Diego, Miguel Angel A1 Alvariño-Piqueras, María A1 Serrano-Marugán, Isabel A1 Díaz-Caneja, Covadonga M. A1 Arango López, Celso A1 Martín Babarro, Javier AB Background There is a need for more sustainable interventions and for assessing the effectiveness of school-based universal anti-bullying programmes in vulnerable populations. We assessed the efficacy of a multicomponent, web-enabled, school-based intervention that aims to improve school climate and reduce bullying (LINKlusive) relative to conventional practices (control condition). Methods We conducted a cluster randomised controlled trial in primary and secondary schools in Madrid, Spain. The primary outcome measure was peer-reported bullying victimisation after the 12-week intervention (study endpoint).We analysed data using longitudinal mixed-effects models. The trial was registered with the ISRCTN registry (15719015). Findings We included 20 schools (10 in each group); 6542 students participated at baseline; 6403 were assessed at study endpoint. After the intervention, there was a statistically significant reduction in bullying victimisation in both the intervention (OR 0.61, 95% CI [0.41, 0.90]) and control groups (OR 0.69, 95% CI [0.51, 0.92]), with no evidence of differences in the whole sample (OR 0.89, 95% CI [0.58, 1.36]; aOR 0.89, 95% CI [0.58, 1.37]). Subgroup analyses showed a statistically significant effect of LINKlusive on bullying victimisation in primary education (aOR 0.68, 95% CI [0.47, 0.98]). In students with peer-reported bullying victimisation at baseline, LINKlusive showed a statistically significant effect on depression (−1.43, 95% CI [−2.46, −0.40], adjusted standardised mean difference(SMD) −0.41) and quality of life (2.18, 95% CI [0.80, 3.56], adjusted SMD 0.45). Interpretation LINKlusive could be effective in reducing bullying victimisation in primary school students. Sustainable whole-school interventions to promote mental health and reduce risk factors are warranted to improveoutcomes in young people, especially in the early years of education. PB The Lancet YR 2024 FD 2024-02 LK https://hdl.handle.net/20.500.14352/116858 UL https://hdl.handle.net/20.500.14352/116858 LA eng NO Arango, C., Martín-Babarro, J., Abregú-Crespo, R., Huete-Diego, M. Á., Alvariño-Piqueras, M., Serrano-Marugán, I., & Díaz-Caneja, C. M. (2024). A web-enabled, school-based intervention for bullying prevention (LINKlusive): a cluster randomised trial. EClinicalMedicine, 68, 102427. https://doi.org/10.1016/j.eclinm.2024.102427 NO Instituto de Salud Carlos III (ISCIII) NO Comisión Europea NO CIBER -Consorcio Centro de Investigación Biomédica en Red NO Gobierno Regional de la Comunidad de Madrid NO Ministerio de Ciencia e Innovación (España) NO Unión Europea (Séptimo Marco de la UE, H2020 y Horizonte Europa ) DS Docta Complutense RD 31 jul 2025