RT Journal Article
T1 Adopting a High-Polyphenolic Diet Is Associated with an Improved Glucose Profile: Prospective Analysis within the PREDIMED-Plus Trial
A1 Tresserra Rimbau, Anna
A1 Castro Barquero, Sara
A1 Becerra Tomás, Nerea
A1 Babio, Nancy
A1 Martínez González, Miguel Ángel
A1 Corella, Dolores
A1 Fitó, Montserrat
A1 Romaguera, Dora
A1 Vioque, Jesús
A1 Alonso Gómez, Ángel M.
A1 Wärnberg, Julia
A1 Martínez, José Alfredo
A1 Serra Majem, Luís
A1 Estruch, Ramon
A1 Tinahones, Francisco J.
A1 Lapetra, José
A1 Pintó, Xavier
A1 Tur, Josep A.
A1 López Miranda, José
A1 Cano Ibáñez, Naomi
A1 Delgado Rodríguez, Miguel
A1 Matía Martín, Pilar
A1 Daimiel, Lidia
A1 Martín Sánchez, Vicente
A1 Vidal, Josep
A1 Vázquez, Clotilde
A1 Ros, Emilio
A1 Basterra, Francisco Javier
A1 Fernández de la Puente, María
A1 Asensio, Eva María
A1 Castañer, Olga
A1 Bullón Vela, Vanessa
A1 Tojal Sierra, Lucas
A1 Gómez Gracia, Enrique
A1 Cases Pérez, Eugenio
A1 Konieczna, Jadwiga
A1 García Ríos, Antonio
A1 Casañas Quintana, Tamara
A1 Bernal López, María Rosa
A1 Santos Lozano, José Manuel
A1 Esteve Luque, Virginia
A1 Bouzas, Cristina
A1 Vázquez Ruiz, Zenaida
A1 Palau Galindo, Antoni
A1 Barragan, Rocio
A1 López Grau, Mercè
A1 Razquín, Cristina
A1 Goicolea Güemez, Leire
A1 Toledo, Estefanía
A1 Vergaz, Manel Vila
A1 Lamuela Raventós, Rosa María
A1 Salas Salvadó, Jordi
AB Previous studies suggested that dietary polyphenols could reduce the incidence and complications of type-2 diabetes (T2D); although the evidence is still limited and inconsistent. This work analyzes whether changing to a diet with a higher polyphenolic content is associated with an improved glucose profile. At baseline, and at 1 year of follow-up visits, 5921 participants (mean age 65.0 ± 4.9, 48.2% women) who had overweight/obesity and metabolic syndrome filled out a validated 143-item semi-quantitative food frequency questionnaire (FFQ), from which polyphenol intakes were calculated. Energy-adjusted total polyphenols and subclasses were categorized in tertiles of changes. Linear mixed-effect models with random intercepts (the recruitment centers) were used to assess associations between changes in polyphenol subclasses intake and 1-year plasma glucose or glycosylated hemoglobin (HbA1c) levels. Increments in total polyphenol intake and some classes were inversely associated with better glucose levels and HbA1c after one year of follow-up. These associations were modified when the analyses were run considering diabetes status separately. To our knowledge, this is the first study to assess the relationship between changes in the intake of all polyphenolic groups and T2D-related parameters in a senior population with T2D or at high-risk of developing T2D.
PB MDPI
SN 2076-3921
YR 2022
FD 2022-02-01
LK https://hdl.handle.net/20.500.14352/73289
UL https://hdl.handle.net/20.500.14352/73289
LA eng
NO The PREDIMED-Plus trial was supported by the Spanish Institutions for funding scientific biomedical research, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn) and Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (six coordinated Fondo de Investigaciones Sanitarias projects leaded by J.S.-S. and J.V. (Josep Vidal), including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532, PI20/00456, PI20/00339, PI20/00557, PI20/00886, PI20/01158)), the Especial Action Project entitled Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus grant to J.S.-S., European Research Council (Advanced Research Grant 2014–2019, 340918) to M.Á.M.-G., the Recercaixa grant to J.S.-S. (2013ACUP00194), grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013, PS0358/2016, and PI0137/2018), a grant from the Generalitat Valenciana (PROMETEO/2017/017), a SEMERGEN grant, a CICYT grant provided by the Ministerio de Ciencia, Innovación y Universidades (AGL2016-75329-R), and funds from the European Regional Development Fund (CB06/03). Food companies Hojiblanca (Lucena, Spain) and Patrimonio Comunal Olivarero (Madrid, Spain) donated extra virgin olive oil for the PTREDIMED-Plus study, and the Almond Board of California (Modesto, CA, USA), American Pistachio Growers (Fresno, CA, USA), and Paramount Farms (Wonderful Company, LLC, Los Angeles, CA, USA) donated nuts for the PREDIMED-Plus pilot study. J.K. supported with Juan de la Cierva-Incorporación research grant (IJC2019-042420-I) of the Spanish Ministry of Economy, Industry and Competitiveness and European Social Funds. This call was co-financed at 50% with charge to the Operational Program FSE 2014-2020 of the Balearic Islands. J.S.-S, senior author of this article, was partially supported by ICREA under the ICREA Academia programme.
NO Unión Europea
NO Consejo Europeo de Investigación
NO Ministerio de Ciencia y Innovación (España)
NO Ministerio de Economía e Industria (España)
NO Junta de Andalucía. Consejería de Salud
NO Generalitat Valenciana
NO Gobierno de Islas Baleares
NO Instituto de Salud Carlos III
NO Recercaixa
NO ICREA
NO PREDIMED-Plus
NO CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn)
DS Docta Complutense
RD 5 ago 2024