RT Journal Article
T1 Combination of Fenugreek and Quinoa Husk as Sources of Steroidal and Triterpenoid Saponins: Bioactivity of Their Co-Extracts and Hydrolysates
A1 Cantero-Bahillo, Emma
A1 Navarro Del Hierro, Joaquín
A1 Siles-Sánchez, María de las Nieves
A1 Jaime, Laura
A1 Santoyo, Susana
A1 Martín, Diana
AB Saponins, both steroidal and triterpenoid, exhibit distinct bioactivities. However, they are not commonly found together in natural sources; instead, sources tend to be rich in one type or another and mainly in the form of saponins rather than the sapogenin aglycones. Developing co-extracts containing both saponin or sapogenin types would be a strategy to harness their respective bioactivities, yielding multibioactive extracts. Therefore, this study evaluates the bioactivity (hypolipidemic, antioxidant, and anti-inflammatory activities) of co-extracts from fenugreek seeds (steroidal-rich saponins) and quinoa husk (triterpenoid-rich saponins), co-extracted at varying proportions, alongside their respective sapogenin-rich hydrolysates. Pancreatic lipase inhibition increased with fenugreek content in co-extracts, especially in sapogenin-rich variants. The latter substantially interfered with cholesterol bioaccessibility (90% vs. 15% in sapogenin-rich extracts). Saponin-rich co-extracts exhibited reduced cytokine release with increased fenugreek content, while sapogenin-rich counterparts showed greater reductions with higher quinoa husk content. Limited cellular antioxidant activities were observed in all extracts, with improved post-hydrolysis bioactivity. Therefore, simultaneous co-extraction of steroidal and triterpenoid sources, such as fenugreek and quinoa husk, as well as their subsequent hydrolysis, are innovative strategies for obtaining multibioactive natural extracts.
PB MDPI
SN 2304-8158
YR 2024
FD 2024-02-12
LK https://hdl.handle.net/20.500.14352/103393
UL https://hdl.handle.net/20.500.14352/103393
LA eng
NO Cantero-Bahillo, E.; Navarro del Hierro, J.; de las Nieves Siles-Sánchez, M.; Jaime, L.; Santoyo, S.; Martin, D. Combination of Fenugreek and Quinoa Husk as Sources of Steroidal and Triterpenoid Saponins: Bioactivity of Their Co-Extracts and Hydrolysates. Foods 2024, 13, 562. https://doi.org/ 10.3390/foods13040562
NO Author Contributions: Conceptualization: E.C.-B., J.N.d.H. and D.M.; formal analysis: E.C.-B. and M.d.l.N.S.-S.; funding acquisition: S.S. and L.J.; investigation: E.C.-B. and MdlNS-S; methodology: J.N.d.H., L.J., S.S. and D.M.; project administration: S.S., L.J. and D.M., supervision: J.N.d.H. and D.M.; writing-original draft: E.C.-B.; writing—review and editing: E.C.-B., J.N.d.H., L.J., S.S. and D.M. All authors have read and agreed to the published version of the manuscript.
NO Ministerio de Ciencia e Innovación
DS Docta Complutense
RD 6 abr 2025