RT Journal Article
T1 Olive leaf extract supplementation improves the vascular and metabolic alterations associated with aging in Wistar rats
A1 González Hedström, Daniel
A1 García Villalón, Ángel Luís
A1 Amor, Sara
A1 Fuente Fernández, María de la
A1 Almodóvar, Paula
A1 Pródanov Pródanov, Marín
A1 Priego Cuadra, Teresa
A1 Martín Velasco, Ana Isabel
A1 Inarejos García, Antonio Manuel
A1 Granado García, Miriam
AB Olive leaves are rich in bioactive substances which exert anti-inflammatory, antioxidant, insulin-sensitizing and antihypertensive effects. The aim of this study was to analyze the possible beneficial effects of an olive leaf extract (OLE) rich in secoiridoids and phenolic compounds on the aging-induced metabolic and vascular alterations. Three experimental groups of rats were used: 3-month-old rats, 24-month-old rats and 24-month-old rats supplemented 21 days with OLE (100 mg/kg). Administration of OLE to aged rats decreased the weight of adrenal glands and prevented the aging-induced loss of body weight and muscle mass. In the serum, OLE reduced the circulating levels of LDL-cholesterol and IL-6 and increased the concentrations of leptin and adiponectin. In the liver OLE attenuated the decreased gene expression of SOD-1, GSR, GCK and GSK-3β and reduced the aging-induced overexpression of NOX-4, Alox-5, iNOS and TNF-α. In aorta segments, OLE prevented endothelial dysfunction and vascular insulin resistance and improved vasoconstriction in response to KCl and NA. Improvement in vascular function was associated with the attenuation of the alterations in the gene expression of COX-2, IL-6, GPx, NOX-1 and IL-10. In conclusion, OLE exerts anti-inflammatory and antioxidant effects in aged rats and attenuates the alterations in vascular function associated with aging.
PB Nature Research
YR 2021
FD 2021
LK https://hdl.handle.net/20.500.14352/88903
UL https://hdl.handle.net/20.500.14352/88903
LA eng
NO González-Hedström, D., García-Villalón, Á.L., Amor, S. et al. Olive leaf extract supplementation improves the vascular and metabolic alterations associated with aging in Wistar rats. Sci Rep 11, 8188 (2021). https://doi.org/10.1038/s41598-021-87628-7
NO Comunidad de Madrid
DS Docta Complutense
RD 20 abr 2025