RT Journal Article T1 Estimating the Prevalence of Recreational Opioid Use in Spain Using a Multiplier Method A1 Pulido Manzanero, José A1 Sánchez Niubo, Albert A1 Llorens, Noelia A1 Hoyos Miller, Juan Eduardo A1 Barrio, Gregorio A1 Belza, Maria Jose A1 Cea Soriano, Trinidad Lucía A1 Angulo Brunet, Ariadna A1 Sordo Delcastillo, Luis AB Acknowledgement of the prevalence of recreational opioid use (PROU) is key to the planning and evaluation of care services. However, in Spain, the prevalence of PROU in recent years is unknown. The objective of this study was to estimate the PROU between 2005 and 2019 in the general populations of six Spanish cities. A benchmark-multiplier methodology was used to estimate the PROU population size. The benchmark used was overdose deaths from recreational opioid use in Spain’s six most populated cities. The multiplier was the overdose death rate in a cohort of heroin users. Linear regression was used to estimate the trend of the PROU estimate over the set period of years. In 2005, the PROU was 4.78 (95%CI 3.16–7.91) per 1000 people. The estimated trend decreased, with the two lowest values being 2.35 per 1000 in 2015 and 2.29 in 2018. In 2019 the PROU was 2.60 per 1000 (95%CI 1.72–4.31), 45% lower than in 2005. While the decline in the PROU continues, its deceleration over the last four years calls for increased vigilance, especially in light of the opioid crisis in North America that has occurred over the last few years. PB MPDI SN 1660-4601 YR 2022 FD 2022-04-15 LK https://hdl.handle.net/20.500.14352/71627 UL https://hdl.handle.net/20.500.14352/71627 LA eng NO Pulido Manzanero, J., Sánchez Niubo, A., Llorens, N. et al. «Estimating the Prevalence of Recreational Opioid Use in Spain Using a Multiplier Method». International Journal of Environmental Research and Public Health, vol. 19, n.o 8, abril de 2022, p. 4815. DOI.org (Crossref), https://doi.org/10.3390/ijerph19084815. NO Acción Estratégica en Salud DS Docta Complutense RD 12 abr 2025