RT Journal Article
T1 The defective gut colonization of Candida albicans hog1 MAPK mutants is restored by overexpressing the transcriptional regulator of the white opaque transition WOR1
A1 Román González, Elvira
A1 Prieto Prieto, Antonio Daniel
A1 Hidalgo Vico, Susana
A1 Alonso Monge, Rebeca María Del Mar
A1 Pla Alonso, Jesús
AB The transcriptional master regulator of the white opaque transition of Candida albicans WOR1 is important for the adaptation to the commensal lifestyle in the mammalian gut, a major source of invasive candidiasis. We have generated cells that overproduce Wor1 in mutants defective in the Hog1 MAP kinase, defective in several stress responses and unable to colonize the mice gut. WOR1 overexpression allows hog1 to be established as a commensal in the murine gut in a commensalism model and even compete with wild-type C. albicans cells for establishment. This increased fitness correlates with an enhanced ability to adhere to biotic surfaces as well as increased proteinase and phospholipase production and a decrease in filamentation in vitro. We also show that hog1 WOR1OE are avirulent in a systemic candidiasis model in mice.
PB Taylor & Francis
YR 2023
FD 2023-12-31
LK https://hdl.handle.net/20.500.14352/128930
UL https://hdl.handle.net/20.500.14352/128930
LA eng
NO Román, E., Prieto, D., Hidalgo-Vico, S., Alonso-Monge, R., & Pla, J. (2023). The defective gut colonization of Candida albicans hog1 MAPK mutants is restored by overexpressing the transcriptional regulator of the white opaque transition WOR1. Virulence, 14(1). https://doi.org/10.1080/21505594.2023.2174294
NO Ministerio de Economía y Competitividad (España)
NO Comunidad de Madrid
DS Docta Complutense
RD 31 dic 2025