RT Journal Article
T1 Maternal Supplementation with Polyphenols and Omega-3 Fatty Acids during Pregnancy: E ects on Growth, Metabolism, and Body Composition of the O spring
A1 De las Heras Molina, Ana
A1 Pesantez-Pacheco, José Luis
A1 Astiz, Susana
A1 Garcia-Contreras, Consolación
A1 Vázquez Gómez, Marta
A1 Encinas Cerezo, María Teresa
A1 Óvilo, Cristina
A1 Isabel Redondo, Beatriz
A1 Gonzalez-Bulnes, Antonio
AB Maternal supplementation with antioxidants and n3 PUFAs may be a promising strategy to reduce the risk of intrauterine growth restriction and preterm delivery, which may diminish the appearance of low-birth-weight neonates. The present study aimed to determine benefits and risks of a dietary supplementation combining hydroxytyrosol, a polyphenol from olive leaves and fruits, and n3 PUFAs, from linseed oil, on developmental patterns and metabolic traits of offspring in swine, a model of IUGR pregnancies. The results obtained indicate that maternal supplementation with hydroxytyrosol and n-3 fatty acids during pregnancy has no deleterious effects on the reproductive traits of the sows (prolificacy, homogeneity of the litter, and percentage of stillborns and low-birth-weight, LBW, piglets) and the postnatal features of the piglets (growth patterns, adiposity, and metabolic traits). Conversely, in spite of a lower mean weight and corpulence at birth, piglets from the supplemented sows showed higher average daily weight gain and fractional growth rate. Thus, at juvenile stages afterwards, the offspring from the treated group reached higher weight and corpulence, with increased muscle development and better lipidemic and fatty acid profiles, in spite of similar adiposity, than offspring in the control group. However, much caution and more research are still needed before practical recommendation and use in human pregnancies.
PB MDPI
YR 2020
FD 2020-12-10
LK https://hdl.handle.net/20.500.14352/92615
UL https://hdl.handle.net/20.500.14352/92615
LA eng
NO Heras-Molina, Ana; Pesantez-Pacheco, Jose Luis; Astiz, Susana; Garcia-Contreras, Consolacion; Vazquez-Gomez, Marta; Encinas, Teresa; Ovilo, Cristina; Isabel, Beatriz; Gonzalez-Bulnes, Antonio. Maternal Supplementation with Polyphenols and Omega-3 Fatty Acids during Pregnancy: Effects on Growth, Metabolism, and Body Composition of the Offspring. ANIMALS. 10 - 11, MDPI, 01/11/2020. ISSN 2076-2615
NO Ministerio de Economía y Competitividad (project AGL2013–48121-C3-2-R and AGL2016–79321-C2–1-R) co-financiado por FEDER
NO Gobierno de España (AHM: FPI National Program Grant BES-2017-080541; CGC: FPI National Program Grant BES-2014-070464; MVG: FPU National Program Grant FPU014/01285).
DS Docta Complutense
RD 9 abr 2025