RT Journal Article
T1 New Mediators in the Crosstalk between Different Adipose Tissues
A1 Gómez Hernández, María De La Almudena
A1 Heras Jiménez, Natalia De Las
A1 González Gálvez, Beatriz
A1 Fernández-Marcelo, Tamara
A1 Fernández Millán, Elisa
A1 Escribano Illanes, Óscar
A2 Frontini, Andrea
AB Adipose tissue is a multifunctional organ that regulates many physiological processes such as energy homeostasis, nutrition, the regulation of insulin sensitivity, body temperature, and immune response. In this review, we highlight the relevance of the different mediators that control adipose tissue activity through a systematic review of the main players present in white and brown adipose tissues. Among them, inflammatory mediators secreted by the adipose tissue, such as classical adipokines and more recent ones, elements of the immune system infiltrated into the adipose tissue (certain cell types and interleukins), as well as the role of intestinal microbiota and derived metabolites, have been reviewed. Furthermore, anti-obesity mediators that promote the activation of beige adipose tissue, e.g., myokines, thyroid hormones, amino acids, and both long and micro RNAs, are exhaustively examined. Finally, we also analyze therapeutic strategies based on those mediators that have been described to date. In conclusion, novel regulators of obesity, such as microRNAs or microbiota, are being characterized and are promising tools to treat obesity in the future.
PB MDPI
SN 1422-0067
YR 2024
FD 2024-04-25
LK https://hdl.handle.net/20.500.14352/104844
UL https://hdl.handle.net/20.500.14352/104844
LA eng
NO European Commission-ERC
NO Ministerio de Ciencia e Innovación (España)
DS Docta Complutense
RD 10 abr 2025