RT Journal Article
T1 The endocannabinoid 2-AG enhances spontaneous remyelination by targeting microglia
A1 Mecha Rodríguez, Miriam
A1 Yanguas Casás, Natalia
A1 Feliú Martínez, Ana
A1 Mestre, L.
A1 Carrillo-Salinas, F.
A1 Azcoitia Elías, Iñigo
A1 Yong, V. W.
A1 Guaza Rodríguez, Carmen
AB Remyelination is an endogenous process by which functional recovery of damaged neurons is achieved by reinstating the myelin sheath around axons. Remyelination has been documented in multiple sclerosis (MS) lesions and experimental models, although it is often incomplete or fails to affect the integrity of the axon, thereby leading to progressive disability. Microglia play a crucial role in the clearance of the myelin debris produced by demyelination and in inflammation-dependent OPC activation, two processes necessary for remyelination to occur. We show here that following corpus callosum demyelination in the TMEV-IDD viral murine model of MS, there is spontaneous and partial remyelination that involves a temporal discordance between OPC mobilization and microglia activation. Pharmacological treatment with the endocannabinoid 2-AG enhances the clearance of myelin debris by microglia and OPC differentiation, resulting in complete remyelination and a thickening of the myelin sheath. These results highlight the importance of targeting microglia during the repair processes in order to enhance remyelination.
PB Elsevier
SN 1090-2139
YR 2019
FD 2019
LK https://hdl.handle.net/20.500.14352/13507
UL https://hdl.handle.net/20.500.14352/13507
LA eng
NO Ministerio de Economía y Competitividad (MINECO)
NO Red Española de Esclerosis Múltiple (REEM)
NO Fondo de Investigación Sanitaria (FIS)
DS Docta Complutense
RD 7 abr 2025