RT Journal Article
T1 Clinical predictors of suicidal acts after major  depression in bipolar disorder: a prospective  study
A1 Galfalvy, Hanga
A1 Oquendo, María A
A1 Carballo Belloso, Juan José
A1 Sher, Leo
A1 Grunebaum, Michael  F
A1 Burke, Ainsley
A1 Mann, J John
AB Objective: This study determined the clinical predictors of suicidal behavior during a 2-year follow-up of patients with bipolar disorder presenting with a major depressive episode (MDE).Method: Sixty four patients with DSM-III-R bipolar disorder were assessed at presentation for treatment of an MDE. Correlates of past suicidal behavior were determined by comparing patients with and without a history of suicide attempts using a t-test, Wilcoxon test or chi-squared test of independence on individual explanatory variables. Putative predictors of attempts during the follow-up period were tested separately using Cox proportional hazards regression analysis.Results: Twelve of 64 patients had at least one suicide attempt in the follow-up period, five of them attempted in the first 2 months and seven around or shortly after the 1-year follow-up visit. All attempters had a history of past suicide attempts. Most predictors of future suicidal behavior were correlates of past suicidal behavior. Family history of suicide acts and comorbid borderline personality disorder predicted early attempts, while younger age, high hostility scores, number of past attempts, subjective pessimism as reflected in depression and suicidal ideation, and few reported reasons for living predicted suicidal acts during the whole period.Conclusion: In this data set of bipolar patients we noted an intriguing picture of two clusters of suicide attempts. Hostility was the strongest risk factor. These findings may have implications in both the identification of at-risk patients and the timing of clinical interventions including aggressive pharmacotherapeutic prophylaxis to prevent relapse or recurrence of depressive symptomatology.
PB Wiley
SN 1398-5647
YR 2006
FD 2006
LK https://hdl.handle.net/20.500.14352/126391
UL https://hdl.handle.net/20.500.14352/126391
LA eng
NO Galfalvy H, Oquendo MA, Carballo JJ, Sher L, Grunebaum MF, Burke A, Mann JJ. Clinical predictors of suicidal acts after major depression in bipolar disorder: a prospective study. Bipolar Disord. 2006 Oct;8(5 Pt 2):586-95
NO NIMH grants MH62185, MH59710
NO The Stanley Medical Research Institute
DS Docta Complutense
RD 18 mar 2026