RT Journal Article T1 Risk factors for suicidal behaviour in late-life depression: A systematic review A1 Fernández Rodrigues, Veronica A1 Sánchez Carro, Yolanda A1 Lagunas, Luisa Natalia A1 Rico Uribe, Laura Alejandra A1 Pemau Gurumeta, Andrés A1 Díaz Carracedo, Patricia A1 Díaz Marsa, Marina Francisca A1 Hervás Torres, Gonzalo A1 De La-Torre Luque, Alejandro Francisco AB BACKGROUNDSuicide is a leading cause of preventable death worldwide, with its peak of maximum incidence in later life. Depression often puts an individual at higher risk for suicidal behaviour. In turn, depression deserves particular interest in old age due to its high prevalence and dramatic impact on health and wellbeing.AIMTo gather integrated evidence on the potential risk factors for suicide behaviour development in depressive older adults, and to examine the effects of depression treatment to tackle suicide behaviour in this population.METHODSA systematic review of empirical studies, published from 2000 onwards, was conducted. Suicidal behaviour was addressed considering its varying forms (i.e., wish to die, ideation, attempt, and completed suicide).RESULTSThirty-five papers were selected for review, comprising both clinical and epidemiological studies. Most of studies focused on suicidal ideation (60%). The studies consistently pointed out that the risk was related to depressive episode severity, psychiatric comorbidity (anxiety or substance use disorders), poorer health status, and loss of functionality. Reduced social support and loneliness were also associated with suicide behaviour in depressive older adults. Finally, the intervention studies showed that suicidal behaviour was a robust predictor of depression treatment response. Reductions in suicidal ideation were moderated by reductions in risk factors for suicide symptoms.CONCLUSIONTo sum up, common and age-specific risk factors seem to be involved in suicide development in depressive older adults. A major effort should be made to tackle this serious public health concern so as to promote older people to age healthily and well.Fernandez-Rodrigues V, Sanchez-Carro Y, Lagunas LN, Rico-Uribe LA, Pemau A, Diaz-Carracedo P, Diaz-Marsa M, Hervas G, de la Torre-Luque A. Risk factors for suicidal behaviour in late-life depression: A systematic review. World J Psychiatry 2022; 12(1): 187-203 [PMID: 35111588 DOI: 10.5498/wjp.v12.i1.187] PB Baishideng Publishing Group SN 2220-3206 YR 2022 FD 2022-01-19 LK https://hdl.handle.net/20.500.14352/131243 UL https://hdl.handle.net/20.500.14352/131243 LA eng NO Fernandez-Rodrigues V, Sanchez-Carro Y, Lagunas LN, Rico-Uribe LA, Pemau A, Diaz-Carracedo P, Diaz-Marsa M, Hervas G, de la Torre-Luque A. Risk factors for suicidal behaviour in late-life depression: A systematic review. World J Psychiatry 2022; 12(1): 187-203 Fernandez-Rodrigues V, Sanchez-Carro Y, Lagunas LN, Rico-Uribe LA, Pemau A, Diaz-Carracedo P, Diaz-Marsa M, Hervas G, de la Torre-Luque A. Risk factors for suicidal behaviour in late-life depression: A systematic review. World J Psychiatry 2022; 12(1): 187-203 [PMID: 35111588 DOI: 10.5498/wjp.v12.i1.187] NO European Regional Development Fund (ERDF) 'a way to build Europe' NO Instituto de Salud Carlos III NO Unión Europea DS Docta Complutense RD 19 mar 2026