RT Journal Article
T1 High MICs for Vancomycin and Daptomycin and Complicated Catheter-Related Bloodstream Infections with Methicillin-Sensitive Staphylococcus aureus.
A1 San Juan Garrido, Rafael
A1 Viedma, Esther
A1 Chaves Sánchez, Fernando
A1 Lalueza, Antonio
A1 Lalueza Blanco, Antonio
A1 Forrtún, Jesús
A1 Loza, Elena
A1 Pujol, Miquel
A1 Ardanuy, Carmen
A1 Morales, Isabel
A1 de Cueto, Marina
A1 Resino-Foz, Elena
A1 Morales-Cartagena, Alejandra
A1 Rico, Alicia
A1 Romero, María
A1 Orellana Miguel, María Ángeles
A1 López Medrano, Francisco
A1 Fernández Ruiz, Mario
A1 Aguado García, José María
AB We investigated the prognostic role of high MICs for antistaphylococcal agents in patients with methicillin-sensitive Staphylococcus aureus catheter-related bloodstream infection (MSSA CRBSI). We prospectively reviewed 83 episodes from 5 centers in Spain during April 2011–June 2014 that had optimized clinical management and analyzed the relationship between E-test MICs for vancomycin, daptomycin, oxacillin, and linezolid and development of complicated bacteremia by using multivariate analysis. Complicated MSSA CRBSI occurred in 26 (31.3%) patients; MICs for vancomycin and daptomycin were higher in these patients (optimal cutoff values for predictive accuracy = 1.5 μg/mL and 0.5 μg/mL). High MICs for vancomycin (hazard ratio 2.4, 95% CI 1.2–5.5) and daptomycin (hazard ratio 2.4, 95% CI 1.1–5.9) were independent risk factors for development of complicated MSSA CRBSI. Our data suggest that patients with MSSA CRBSI caused by strains that have high MICs for vancomycin or daptomycin are at increased risk for complications.
PB Centers for Disease Control and Prevention
YR 2016
FD 2016-06
LK https://hdl.handle.net/20.500.14352/117524
UL https://hdl.handle.net/20.500.14352/117524
LA eng
NO San-Juan R, Viedma E, Chaves F, Lalueza A, Fortún J, Loza E, Pujol M, Ardanuy C, Morales I, de Cueto M, Resino-Foz E, Morales-Cartagena A, Rico A, Romero MP, Orellana MÁ, López-Medrano F, Fernández-Ruiz M, Aguado JM. High MICs for Vancomycin and Daptomycin and Complicated Catheter-Related Bloodstream Infections with Methicillin-Sensitive Staphylococcus aureus. Emerg Infect Dis. 2016 Jun;22(6):1057-66. doi: 10.3201/eid2206.151709. PMID: 27192097; PMCID: PMC4880091.
NO Ministerio de Economía y Competitividad   (REIPI RD12/0015).
NO Instituto de Salud Carlos III
NO Red Española de Investigación en Enfermedades Infecciosas
DS Docta Complutense
RD 9 abr 2025