%0 Journal Article
%A Sánchez Morla, Eva María
%A García‐Jiménez, M.A
%A Barabash Bustelo, Ana
%A Martínez‐Vizcaíno, Vicente
%A Mena, J
%A Cabranes Díaz, José Antonio
%A Baca‐Baldomero, Enrique
%A Santos Góez, José Luis
%T P50 sensory gating deficit is a common marker of vulnerability to bipolar disorder and schizophrenia
%D 2008
%@ 0001-690X
%@ 1600-0447
%U https://hdl.handle.net/20.500.14352/114842
%X Objective: P50 gating in schizophrenia has contributed much to our understanding of the pathophysiology of the illness. We examined euthymic bipolar patients to determine if they also have a P50 gatingdeficit.Method: P50 gating was measured in 81 euthymic bipolar patients (50 with a lifetime history of psychotic symptoms), 92 stable schizophrenic patients, and 67 control subjects.Results: P50 gating was significantly lower in control subjects than in bipolar patients with a lifetime history of psychosis (P = 0.001) and schizophrenic patients (P = 0.0001). In all patient groups, the percentage of patients with P50 gating was higher than in the control group (v2 = 30.596; P < 0.0001). There was no statistically significant correlation between P50 gating and other clinical variables.Conclusion: Our data suggest that P50 gating deficit is a neurobiological marker that is present in stable schizophrenic patients and euthymic bipolar patients.
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