RT Journal Article
T1 P50 sensory gating deficit is a common marker of vulnerability to bipolar disorder and schizophrenia
A1 Sánchez Morla, Eva María
A1 García‐Jiménez, M.A
A1 Barabash Bustelo, Ana
A1 Martínez‐Vizcaíno, Vicente
A1 Mena, J
A1 Cabranes Díaz, José Antonio
A1 Baca‐Baldomero, Enrique
A1 Santos Góez, José Luis
AB Objective: P50 gating in schizophrenia has contributed much to our understanding of the pathophysiology of the illness. We examined euthymic bipolar patients to determine if they also have a P50 gatingdeficit.Method: P50 gating was measured in 81 euthymic bipolar patients (50 with a lifetime history of psychotic symptoms), 92 stable schizophrenic patients, and 67 control subjects.Results: P50 gating was significantly lower in control subjects than in bipolar patients with a lifetime history of psychosis (P = 0.001) and schizophrenic patients (P = 0.0001). In all patient groups, the percentage of patients with P50 gating was higher than in the control group (v2 = 30.596; P < 0.0001). There was no statistically significant correlation between P50 gating and other clinical variables.Conclusion: Our data suggest that P50 gating deficit is a neurobiological marker that is present in stable schizophrenic patients and euthymic bipolar patients.
PB WILEY
SN 0001-690X
SN 1600-0447
YR 2008
FD 2008
LK https://hdl.handle.net/20.500.14352/114842
UL https://hdl.handle.net/20.500.14352/114842
LA eng
NO Sánchez‐Morla, E. M., et al. «P50 Sensory Gating Deficit Is a Common Marker of Vulnerability to Bipolar Disorder and Schizophrenia». Acta Psychiatrica Scandinavica, vol. 117, n.º 4, abril de 2008, pp. 313-18. DOI.org (Crossref), https://doi.org/10.1111/j.1600-0447.2007.01141.x.
NO Instituto de Ciencias de la Salud de Castilla la Mancha
DS Docta Complutense
RD 9 abr 2025