%0 Journal Article
%A Machuca Marcos, Andrés
%A garcía-calvo, estefanía
%A anunciacao, Daniela S.
%A Luque García, José Luis
%T Rhodium Nanoparticles as a Novel Photosensitizing Agent in Photodynamic Therapy against Cancer
%D 2020
%U https://hdl.handle.net/20.500.14352/105859
%X Photodynamic therapy (PDT) is a promising alter-native treatment for different types of cancer due to its highselectivity, which prevents healthy tissues from being dam-aged. The use of nanomaterials in PDT has several advantag-es over classical photosensitizing agents, due to their uniqueproperties and their capacity for functionalization. Especiallyinteresting is the use of metallic nanoparticles, which are ca-pable of absorbing electromagnetic radiation and eithertransferring this energy to oxygen molecules for the genera-tion of reactive oxygen species (ROS) or dissipating it asheat. Although previous reports have demonstrated the ca-pacity of Rh derivatives to serve as anti-tumor drugs, to thebest of our knowledge there have been no studies on thepotential use of small-sized Rh nanoparticles as photosensi-tizers in PDT. In this study, 5 nm Rh nanoparticles have beensynthesized and their potential in PDT has been evaluated.The results show that treatment with Rh nanoparticles fol-lowed by NIR irradiation induces apoptosis in cancer cellsthrough a p53-independent mechanism.
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