RT Journal Article
T1 Structural, Functional and Neurochemical Cortical Brain Changes Associated with Chronic Low Back Pain
A1 Medrano Escalada, Yara
A1 Plaza Manzano, Gustavo
A1 Fernández-de-las-Peñas, César
A1 Valera Calero, Juan Antonio
AB Chronic low back pain (CLBP) is one of the most prevalent musculoskeletal disorders, being one of the leading contributors to disability worldwide and involving an important economic and social burden. Up to 90% of CLBP is non-specific (not associated with specific injuries), with a chronicity expectation estimated at 10%. Currently, motivational and emotional central circuits are being investigated due to their role in CLBP persistency and chronification. Therefore, this narrative review aimed to summarize the evidence regarding the cortical brain changes described for proposing novel multidisciplinary approaches. Novel advances in neuroimaging techniques demonstrated structural (e.g., decrease in the grey matter located at the dorsolateral prefrontal cortex), functional (e.g., connectivity impairments in those areas involved in pain processing), and neurochemical changes (e.g., decrease in cerebral metabolites). In addition, significant changes were found in the primary somatosensory and motor cortex, contributing to the alteration of low back muscles activation and function
PB MDPI
SN 2379-139X
YR 2022
FD 2022
LK https://hdl.handle.net/20.500.14352/72161
UL https://hdl.handle.net/20.500.14352/72161
LA eng
DS Docta Complutense
RD 7 abr 2025