RT Journal Article
T1 Role of cellular prion protein on LTP expression in aged mice
A1 Maglio, Laura E.
A1 Martins, Vlima R.
A1 Izquierdo, Iván
A1 Ramírez, Oscar A.
AB AbstractCellular prion protein (PrP(c)) has been associated with some physiological functions in the last few years. In a previous paper, we have demonstrated an increased hippocampal synaptic transmission in adult mice lacking this protein. In the present study, we investigate the impact of aging on the generation and maintenance of hippocampal long-term Potentiation (LTP) in 9-month-old mice devoid of PrP(c) protein (Prnp(0/0)). We observed a lower threshold for inducing LTP in 9-month-old Prnp(0/0) mice compared to wild-type ones at the same age. The maintenance of dentate gyrus LTP was more persistent in hippocampal slices from Prnp(0/0) mice. Furthermore, the expression of mRNA for NR2A and NR2B subunits of the NMDA glutamatergic receptor in hippocampus of aged Prnp(0/0) animals showed an increase compared to the wild type. We propose that increased hippocampal glutamatergic transmission in Prnp(0/0) mice is related to the enhanced plasticity and persistence of the dentate LTP.
PB Elsevier
YR 2006
FD 2006-06-30
LK https://hdl.handle.net/20.500.14352/128907
UL https://hdl.handle.net/20.500.14352/128907
LA eng
NO Maglio, Laura E., et al. «Role of Cellular Prion Protein on LTP Expression in Aged Mice». Brain Research, vol. 1097, n.o 1, junio de 2006, pp. 11-18.  https://doi.org/10.1016/j.brainres.2006.04.056.
DS Docta Complutense
RD 20 mar 2026