RT Journal Article
T1 Regulating peroxisome proliferator activated receptor gamma coactivator-1alpha (PGC-1α): A potential role in neurological disorder and treatment
A1 Guo, Pu
A1 Lu, Qirong
A1 Ye, Xiaochun
A1 Martínez Caballero, María Aranzazu
A1 López Torres, Bernardo
A1 Martínez Caballero, Marta
A1 Martínez Larrañaga, María Rosa
A1 Wang, Xu
A1 Anadón Navarro, Arturo Ramón
A1 Ares Lombán, Irma
AB Neurological disorders are catastrophic and challenging conditions that affect central nervous system. They constitute a major health problem worldwide and place a huge economic burden on society and individuals. Extensive evidence has shown that peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1α) is an essential macromolecule that could be targeted to ameliorate the pathology of neurological disorders. This review is the first to summarize studies that have used therapeutics targeted to influence PGC-1α transcription and/or protein abundance/stability to treat neurological diseases. Moreover, the therapeutic target role of PGC-1α has been clarified in neurological disorders from the potential therapeutic agent that targets PGC-1α, for example, chemical agents, proteins and peptides, nucleic acids, and natural extracts. The scientific evidence summarized in this review demonstrates that targeting PGC-1α is an effective strategy for the treatment of neurological disorders. Moreover, PGC-1α could be used as a target to screen or discover new safe and effective natural products, chemical compounds, nucleic acids, or proteins for treating neurological disorders. This review provides new insights that targeting PGC-1α is an efficient strategy for the therapy of neurological disorders and providing key protein target for developing and screening new, safe, and effective PGC-1α agonists against neurological disorders.
PB Elsevier
SN 0014-2999
YR 2025
FD 2025
LK https://hdl.handle.net/20.500.14352/121121
UL https://hdl.handle.net/20.500.14352/121121
LA eng
NO Pu Guo, Qirong Lu, Xiaochun Ye, María-Aránzazu Martínez, Bernardo Lopez-Torres, Marta Martínez, María-Rosa Martínez-Larrañaga, Xu Wang, Arturo Anadón, Irma Ares, Regulating peroxisome proliferator activated receptor gamma coactivator-1alpha (PGC-1α): A potential role in neurological disorder and treatment, European Journal of Pharmacology, Volume 1001, 2025, 177750, https://doi.org/10.1016/j.ejphar.2025.177750.
NO Authorship contribution statement:Pu Guo: Writing – review & editing, Methodology, Investigation, Formal analysis, Data curation, Conceptualization. Qirong Lu: Writing – review & editing, Methodology, Investigation, Formal analysis, Data curation, Conceptualization. Xiaochun Ye: Writing – review & editing, Methodology, Investigation, Formal analysis, Data curation, Conceptualization. María-Aránzazu Martínez: Writing – review & editing, Writing – original draft, Visualization, Funding acquisition, Conceptualization. Bernardo Lopez-Torres: Writing – review & editing, Methodology, Investigation, Formal analysis, Data curation, Conceptualization. Marta Martínez: Writing – review & editing, Methodology, Investigation, Formal analysis, Data curation, Conceptualization. María-Rosa Martínez-Larrañaga: Writing – review & editing, Methodology, Investigation, Formal analysis, Data curation, Conceptualization. Xu Wang: Writing – review & editing, Writing – original draft, Visualization, Funding acquisition, Conceptualization. Arturo Anadón: Writing – review & editing, Writing – original draft, Visualization, Funding acquisition, Conceptualization. Irma Ares: Writing – review & editing, Methodology, Investigation, Formal analysis, Data curation, Conceptualization.
DS Docta Complutense
RD 19 dic 2025