%0 Journal Article
%A Díaz Navarro, Marta
%A Hafian, Rama
%A Pérez Granda, María Jesús
%A Cercenado Mansilla, Emilia
%A Muñoz García, Patricia Carmen
%A Guembe, María
%T Addressing catheter lock therapy: Does heparin reduce the bioactivity of dalbavancin when together in solution during freezing?
%D 2024
%@ 2529-993X
%U https://hdl.handle.net/20.500.14352/111245
%X Introduction: The possible use of dalbavancin as a catheter lock solution was previously demonstrated by our study group. However, it was needed to assess whether heparin could affect dalbavancin bioactivity during freezing storage.Methods: We tested the bioactivity of a dalbavancin+heparin (DH) vs. dalbavancin (D) against Staphylococcal biofilms comparing DH median value of cfu counts and metabolic activity with that obtained for D before and during storage under freezing up to 6 months.Results: Despite there was a slight decrease in the median percentage reduction of metabolic activity at month 3 in Staphylococcus epidermidis between DH and D (97.6 vs. 100, p=0.037), considering the clinical criteria, no significant reduction in any of the variables tested was observed at the end of the experiment between D and DH solutions.Conclusion: The addition of heparin to a dalbavancin lock solution did not affect its bioactivity against staphylococcal biofilms irrespective of its preservation time under freezing.Keywords: Bioactividad; Bioactivity; Biofilms; Biopelículas; Congelación; Dalbavancin; Dalbavancina; Freezing; Heparin; Heparina; Lock therapy; Terapia de sellado.
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