RT Journal Article T1 Macular Thickness as a Potential Biomarker of Mild Alzheimer's Disease A1 García Martín, Elena Salobrar A1 Rojas López, Blanca A1 Ramírez Sebastián, Ana Isabel A1 Hoz Montañana, Rosa de A1 Salazar Corral, Juan José A1 Yubero Pancorbo, Raquel A1 Gil, Pedro A1 Triviño Casado, Alberto A1 Ramirez Sebastian, Jose Manuel AB Although several postmortem findings in the retina of patients with Alzheimer's disease (AD) are available, new biomarkers for early diagnosis and follow-up of AD are still lacking. It has been postulated that the defects in the retinal nerve fiber layer (RNFL) may be the earliest sign of AD, even before damage to the hippocampal region that affects memory. This fact may reflect retinal neuronal-ganglion cell death and axonal loss in the optic nerve in addition to aging. PB Elsevier / American Academy of Ophthalmology SN 0161-6420 YR 2014 FD 2014-03-18 LK https://hdl.handle.net/20.500.14352/35304 UL https://hdl.handle.net/20.500.14352/35304 LA eng NO 1. Hinton DR, Sadun AA, Blanks JC, et al. Optic-nerve degeneration in Alzheimer’s disease. N Engl J Med 1986;315:485–7.2. He XF, Liu YT, Peng C, et al. Optical coherence tomography assessed retinal nerve fiber layer thickness in patients with Alzheimer’s disease: a meta-analysis. Int J Ophthalmol 2012;5:401–5.3. Blanks JC, Torigoe Y, Hinton DR, et al. Retinal pathology in Alzheimer’s disease. I. ganglion cell loss in foveal/parafoveal retina. Neurobiol Aging 1996;17:377–84.4. Tzekov RT, Mullan M. Vision function abnormalities in alzheimer’s disease. Surv Ophthalmol 2013; In press: http://dx.doi.org/10.1016/j.survophthal.2013.10.002.5. Koronyo Y, Salumbides BC, Black KL, et al. Alzheimer’s disease in the retina: Imaging retinal ab plaques for early diagnosis and therapy assessment. Neurodeg Dis 2012;10:285–93. NO Ministerio de Ciencia e Innovación (MICINN) NO Redes temáticas de investigación cooperativa en salud (RETICs) DS Docta Complutense RD 30 abr 2024