RT Journal Article
T1 The effect of immediate postoperative Boussignac CPAP on adverse pulmonary events after thoracic surgery: A multicentre, randomised controlled trial
A1 Puente Maestu, Luis
A1 López, Eloísa
A1 Sayas Catalán, Javier
A1 Alday, Enrique
A1 Planas, Antonio
A1 Parise, Diego J.
A1 Martínez Borja, Marcos
A1 Garutti Martínez, Ignacio
AB AbstractBackground: The effectiveness of prophylactic continuous positive pressure ventilation (CPAP) after thoracic surgery is not clearly established.Objective: The aim of this study was to assess the effectiveness of CPAP immediately after lung resection either by thoracotomy or thoracoscopy in preventing atelectasis and pneumonia.Design: A multicentre, randomised, controlled, open-label trial.Settings: Four large University hospitals at Madrid (Spain) from March 2014 to December 2016.Patients: Immunocompetent patients scheduled for lung resection, without previous diagnosis of sleep-apnoea syndrome or severe bullous emphysema. Four hundred and sixty-four patients were assessed, 426 were randomised and 422 were finally analysed.Intervention: Six hours of continuous CPAP through a Boussignac system versus standard care.Main outcome measures: Primary outcome: incidence of the composite endpoint 'atelectasis + pneumonia'. Secondary outcome: incidence of the composite endpoint 'persistent air leak + pneumothorax'.Results: The primary outcome occurred in 35 patients (17%) of the CPAP group and in 58 (27%) of the control group [adjusted relative risk (ARR) 0.53, 95% CI 0.30 to 0.93]. The secondary outcome occurred in 33 patients (16%) of the CPAP group and in 29 (14%) of the control group [ARR 0.92, 95% CI 0.51 to 1.65].Conclusion: Prophylactic CPAP decreased the incidence of the composite endpoint 'postoperative atelectasis + pneumonia' without increasing the incidence of the endpoint 'postoperative persistent air leaks + pneumothorax'.
PB Lippincott, Williams & Wilkins
SN 0265-0215
YR 2021
FD 2021-02-01
LK https://hdl.handle.net/20.500.14352/98620
UL https://hdl.handle.net/20.500.14352/98620
LA eng
NO Puente-Maestú L, López E, Sayas J, Alday E, Planas A, Parise DJ, Martínez-Borja M, Garutti I; PI12/02734 study group. The effect of immediate postoperative Boussignac CPAP on adverse pulmonary events after thoracic surgery: A multicentre, randomised controlled trial. Eur J Anaesthesiol. 2021 Feb 1;38(2):164-170. doi: 10.1097/EJA.0000000000001369. PMID: 33186306.
NO Instituto de Salud Carlos III
NO Unión Europea
NO NEUMOMADRID (Madrid Pneumological society).
DS Docta Complutense
RD 14 dic 2025