%0 Journal Article
%A Casanova, Javier
%A Garutti Martínez, Ignacio
%A Simón Adiego, Carlos María
%A Giraldez, Ana
%A Martín,  Beatriz
%A González Casaurrán, Guillermo
%A Azcárate Perea, Leire
%A García Martín, M. Cruz
%A Vara Ameigeiras, Elena María
%T The effects of anesthetic preconditioning with sevoflurane in an experimental lung autotransplant model in pigs
%D 2011
%@ 0003-2999
%U https://hdl.handle.net/20.500.14352/97492
%X Background: Ischemia-reperfusion lung injury is doubly important in thoracic surgery because of the associated ventilation damage to 1 lung. In this study we evaluated the cytoprotective effects of sevoflurane in a pulmonary autotransplant model in pigs.Methods: Twenty Large White pigs undergoing pneumonectomy plus lung autotransplant were divided into 2 10-member groups on the basis of the anesthetic received (propofol or sevoflurane). Proinflammatory mediators, oxidative stress, nitric oxide metabolism, and hemodynamic and blood variables were measured at 5 different time points.Results: There was an increase of oxidative stress markers and proinflammatory mediators in the propofol group, whereas the hemodynamic variables were similar in both groups.Conclusions: We demonstrated that sevoflurane decreased the inflammatory response and oxidative stress in a live ischemia-reperfusion lung model.
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