RT Journal Article
T1 The effects of anesthetic preconditioning with sevoflurane in an experimental lung autotransplant model in pigs
A1 Casanova, Javier
A1 Garutti Martínez, Ignacio
A1 Simón Adiego, Carlos María
A1 Giraldez, Ana
A1 Martín, Beatriz
A1 González Casaurrán, Guillermo
A1 Azcárate Perea, Leire
A1 García Martín, M. Cruz
A1 Vara Ameigeiras, Elena María
AB Background: Ischemia-reperfusion lung injury is doubly important in thoracic surgery because of the associated ventilation damage to 1 lung. In this study we evaluated the cytoprotective effects of sevoflurane in a pulmonary autotransplant model in pigs.Methods: Twenty Large White pigs undergoing pneumonectomy plus lung autotransplant were divided into 2 10-member groups on the basis of the anesthetic received (propofol or sevoflurane). Proinflammatory mediators, oxidative stress, nitric oxide metabolism, and hemodynamic and blood variables were measured at 5 different time points.Results: There was an increase of oxidative stress markers and proinflammatory mediators in the propofol group, whereas the hemodynamic variables were similar in both groups.Conclusions: We demonstrated that sevoflurane decreased the inflammatory response and oxidative stress in a live ischemia-reperfusion lung model.
SN 0003-2999
YR 2011
FD 2011-10-01
LK https://hdl.handle.net/20.500.14352/97492
UL https://hdl.handle.net/20.500.14352/97492
LA eng
NO Casanova J, Garutti I, Simon C, Giraldez A, Martin B, Gonzalez G, Azcarate L, Garcia C, Vara E. The effects of anesthetic preconditioning with sevoflurane in an experimental lung autotransplant model in pigs. Anesth Analg. 2011 Oct;113(4):742-8. doi: 10.1213/ANE.0b013e3182288e01. Epub 2011 Sep 2. PMID: 21890883.
NO Instituto de Salud Carlos III
NO LABORATORIOS ABBOT
NO SOCIEDAD ESPAÑOLA  NEUMOLOGÍA Y CIRUGÍA TORÁCICA
DS Docta Complutense
RD 5 abr 2025