RT Journal Article
T1 Complement as a Therapeutic Target in Systemic Autoimmune Diseases
A1 Galindo Izquierdo, María
A1 Pablos Álvarez, José Luis
AB The complement system (CS) includes more than 50 proteins and its main function is to recognize and protect against foreign or damaged molecular components. Other homeostatic functions of CS are the elimination of apoptotic debris, neurological development, and the control of adaptive immune responses. Pathological activation plays prominent roles in the pathogenesis of most autoimmune diseases such as systemic lupus erythematosus, antiphospholipid syndrome, rheumatoid arthritis, dermatomyositis, and ANCA-associated vasculitis. In this review, we will review the main rheumatologic autoimmune processes in which complement plays a pathogenic role and its potential relevance as a therapeutic target.
PB MPDI
SN 2073-4409
YR 2021
FD 2021-01-13
LK https://hdl.handle.net/20.500.14352/7131
UL https://hdl.handle.net/20.500.14352/7131
LA eng
NO Instituto de Salud Carlos III (ISCIII)/ FEDER
DS Docta Complutense
RD 23 abr 2025