RT Journal Article
T1 Spatial analysis of thickness changes in ten retinal layers of Alzheimer’s disease patients based on optical coherence tomography
A1 Jañez Escalada, Luis
A1 Jáñez García, Lucía
A1 García Martín, Elena Salobrar
A1 Santos Mayo, Alejandro
A1 Hoz Montañana, María Rosa de
A1 Yubero Pancorbo, Raquel
A1 Gil Gregorio, Pedro
A1 Ramirez Sebastian, Jose Manuel
AB The retina is an attractive source of biomarkers since it shares many features with the brain. Thickness differences in 10 retinal layers between 19 patients with mild Alzheimer’s disease (AD) and a control group of 24 volunteers were investigated. Retinal layers were automatically segmented and their thickness at each scanned point was measured, corrected for tilt and spatially normalized. When the mean thickness of entire layers was compared between patients and controls, only the outer segment layer of patients showed statistically significant thinning. However, when the layers were compared point-by point, patients showed statistically significant thinning in irregular regions of total retina and nerve fiber, ganglion cell, inner plexiform, inner nuclear and outer segment layers. Our method, based on random field theory, provides a precise delimitation of regions where total retina and each of its layers show a statistically significant thinning in AD patients. All layers, except inner nuclear and outer segments, showed thickened regions. New analytic methods have shown that thinned regions are interspersed with thickened ones in all layers, except inner nuclear and outer segments. Across different layers we found a statistically significant trend of the thinned regions to overlap and of the thickened ones to avoid overlapping.
PB Nature Publishing Group
SN 2045-2322
YR 2019
FD 2019
LK https://hdl.handle.net/20.500.14352/13590
UL https://hdl.handle.net/20.500.14352/13590
LA eng
NO Received: 4 March 2019; Accepted: 24 August 2019; Published: 10 September 2019
NO Instituto de Salud Carlos III
NO Ministerio de Educación, Cultura y Deporte
DS Docta Complutense
RD 16 may 2024