RT Journal Article
T1 The Cdk1/Cdk2 homolog CDKA;1 controls the recombination landscape in Arabidopsis
A1 Wijnker, Erik
A1 Harashima, Hirofumi
A1 Müller, Katja
A1 Parra Núñez, Pablo
A1 Bastiaan de Snoo, C.
A1 Van de Belt, José
A1 Dissmeyer, Nico
A1 Bayer, Martin
A1 Pradillo Orellana, Mónica
A1 Schnittger, Arp
AB Little is known how patterns of cross-over (CO) numbers and distribution during meiosis are established. Here, we reveal that cyclin-dependent kinase A;1 (CDKA;1), the homolog of human Cdk1 and Cdk2, is a major regulator of meiotic recombination in Arabidopsis. Arabidopsis plants with reduced CDKA;1 activity experienced a decrease of class I COs, especially lowering recombination rates in centromere-proximal regions. Interestingly, this reduction of type I CO did not affect CO assurance, a mechanism by which each chromosome receives at least one CO, resulting in all chromosomes exhibiting similar genetic lengths in weak loss-of-function cdka;1 mutants. Conversely, an increase of CDKA;1 activity resulted in elevated recombination frequencies. Thus, modulation of CDKA;1 kinase activity affects the number and placement of COs along the chromosome axis in a dose-dependent manner.
PB National Academy of Sciences
SN 0027-8424, ESSN: 1091-6490
YR 2019
FD 2019-06
LK https://hdl.handle.net/20.500.14352/13834
UL https://hdl.handle.net/20.500.14352/13834
LA eng
NO Unión Europea. FP7
NO Ministerio de Ciencia e Innovación (MICINN)
NO European Molecular Biology Organization
DS Docta Complutense
RD 26 dic 2025