RT Journal Article
T1 The Neurotoxic Role of Extracellular Tau Protein
A1 Sebastián Serrano, Álvaro
A1 Diego García, Laura de
A1 Díaz Hernández, Miguel
AB Tauopathies are a class of neurodegenerative diseases associated with the microtubuleassociated protein tau, with Alzheimer’s disease (AD) being the most prevalent related disorder. Neurofibrillary tangles (NFTs) are one of the neuropathological hallmarks present in the brains of AD patients. Because NFTs are aberrant intracellular inclusions formed by hyperphosphorylated tau, it was initially proposed that phosphorylated and/or aggregated intracellular tau protein was causative of neuronal death. However, recent studies suggest a toxic role for non-phosphorylated and non-aggregated tau when it is located in the brain extracellular space. In this work, we will discuss the neurotoxic role of extracellular tau as well its involvement in the spreading of tau pathologies.
PB MDPI
SN 1422-0067
YR 2018
FD 2018-03-27
LK https://hdl.handle.net/20.500.14352/12517
UL https://hdl.handle.net/20.500.14352/12517
LA eng
NO Unión Europea. Horizonte 2020
NO Ministerio de Ciencia y Educación
NO Universidad Complutense de Madrid/Banco de Santander
DS Docta Complutense
RD 6 abr 2025