RT Journal Article
T1 Temozolomide induces radiologic pseudoprogression and tumor cell vanishing in oligodendroglioma
A1 Hernández Laín, Aurelio
A1 Hilario Barrio, Amaya
A1 Sepúlveda, Juan Manuel
A1 Cantero, Diana
A1 Ramos González, Ana
A1 Pérez Núñez, Ángel
AB Enhanced MRI monitoring has shown that many patients with early radiologic findings of progressive lesions after treatment do not have true tumor progression. Radiologic pseudoprogression occurs in one third of all patients with glioblastoma. Classically, these patients present with an increase in contrast-enhancing lesion size within 12 weeks after finishing chemoradiation therapy followed by subsequent improvement or stabilization without any further treatment. In follow-up MRI studies, our 2 patients showed slow and progressive enlargement in T2/FLAIR hyperintensity, one with nodular morphology, with no contrast enhancement. Our findings raise the possibility that TMZ alone without radiotherapy may also result in radiologic pseudoprogression. Reactive and inflammatory changes seen in the surrounding brain could explain this phenomenon. Therefore, we suggest caution regarding aggressive resection in patients with suspected radiologic pseudoprogression.
PB Wolters Kluwer
YR 2016
FD 2016-07-05
LK https://hdl.handle.net/20.500.14352/115598
UL https://hdl.handle.net/20.500.14352/115598
LA eng
NO Hernandez-Lain A, Hilario A, Sepulveda JM, Cantero D, Ramos A, Perez-Nuñez A. Temozolomide induces radiologic pseudoprogression and tumor cell vanishing in oligodendroglioma. Neurology. 2016 Jul 5;87(1):114-5. doi: 10.1212/WNL.0000000000002810. Epub 2016 Jun 1. PMID: 27251883
NO Ministerio de Economía y Competitividad (España)
DS Docta Complutense
RD 4 abr 2025