%0 Journal Article
%A García Csaky, Aurelio
%A Roscales García, Silvia
%T Synthesis of ketones by C-H functionalization of aldehydes with boronic acids under transition-metal-free conditions
%D 2021
%@ 1521-3773
%U https://hdl.handle.net/20.500.14352/113460
%X A method for the synthesis of ketones from aldehydes and boronic acids via a transition-metal-free C−H functionalization reaction is reported. The method employs nitrosobenzene as a reagent to drive the simultaneous activation of the boronic acid as a boronate and the activation of the C−H bond of the aldehyde as an iminium species that triggers the key C−C bond-forming step via an intramolecular migration from boron to carbon. These findings constitute a practical, scalable, and operationally straightforward method for the synthesis of ketones.
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