RT Journal Article
T1 Propagation Failure Along Myelinated Nerves
A1 Carpio, Ana
A1 Peral, I.
AB Propagation of traveling pulses in the myelinated Hodgkin-Huxley model is studied. The nerve impulse is a traveling wave with two components. At the Ranvier nodes, it behaves as a discrete traveling pulse. Wave motion through the internodal regions is then driven by this traveling pulse. We give analytical characterizations of the parameter ranges for which nerve impulses fail to propagate by exploiting time scale separation and the active node approximation, which reduces the dynamics of infinite fibers to the evolution of a few nodes. Simple recipes to predict the speed of the impulses and the widths of their peaks are also given. Predictions are in good agreement with the information provided by numerical simulations.
PB Springer
SN 0938-8974
YR 2011
FD 2011
LK https://hdl.handle.net/20.500.14352/42107
UL https://hdl.handle.net/20.500.14352/42107
LA eng
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NO Spanish Ministry of Research
NO Autonomous Region of Madrid
DS Docta Complutense
RD 2 may 2024