RT Journal Article
T1 Presence of methylated arginine derivatives in orthotopic human liver transplantation: Relevance for liver function
A1 Martín Sanz, Paloma
A1 Olmedilla, Luis
A1 Dulin, Elena
A1 Casado, Marta
A1 Callejas, Nuria A.
A1 Pérez Peña, José M.
A1 Garutti Martínez, Ignacio
A1 Sanz, Javier M.
A1 Calleja, Javier
A1 Barrigón Vázquez, Santos
A1 Bosca Gomar, Lisardo
AB Orthotopic liver transplantation (OLT) is a frequent option in the treatment of liver diseases. During the cold ischemia period of the donor liver, there is an accumulation of metabolites that are potent inhibitors of the cytokine-inducible and endothelial nitric oxide synthase isoenzymes. We identified the presence of L-N-monomethylarginine and asymmetric dimethylarginine (ADMA) as the main inhibitors by means of analytic high-pressure liquid chromatography and mass spectrometry techniques. An average ADMA concentration of 450 micromol/L was measured in the preservation medium of donor livers with poor outcomes after OLT. A statistically significant relationship was observed between the concentration of methylated arginine derivatives in the graft and liver function after OLT. These data suggest that measurement of methylated arginine, released after liver protein catabolism, might provide an indication of functional status of the liver that can help the development of strategies intended to improve graft viability.
PB Wiley
SN 1527-6465
SN 1527-6465
YR 2003
FD 2003-01-01
LK https://hdl.handle.net/20.500.14352/98639
UL https://hdl.handle.net/20.500.14352/98639
LA eng
NO Martín-Sanz P, Olmedilla L, Dulin E, Casado M, Callejas NA, Pérez-Peña J, Garutti I, Sanz J, Calleja J, Barrigón S, Boscá L. Presence of methylated arginine derivatives in orthotopic human liver transplantation: relevance for liver function. Liver Transpl. 2003 Jan;9(1):40-8. doi: 10.1053/jlts.2003.50008. PMID: 12514772.
NO Universidad Complutense de Madrid
NO Comunidad de Madrid
DS Docta Complutense
RD 6 abr 2025