RT Journal Article
T1 Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease
A1 Burillo Maldonado, Jesús
A1 Marqués, Patricia
A1 Jiménez, Beatriz
A1 González-Blanco, Carlos
A1 Benito De Las Heras, Manuel R.
A1 Guillén Viejo, Carlos
AB Type 2 diabetes mellitus is a progressive disease that is characterized by the appearance of insulin resistance. The term insulin resistance is very wide and could affect different proteins involved in insulin signaling, as well as other mechanisms. In this review, we have analyzed the main molecular mechanisms that could be involved in the connection between type 2 diabetes and neurodegeneration, in general, and more specifically with the appearance of Alzheimer's disease. We have studied, in more detail, the different processes involved, such as inflammation, endoplasmic reticulum stress, autophagy, and mitochondrial dysfunction.
YR 2021
FD 2021-05-18
LK https://hdl.handle.net/20.500.14352/113497
UL https://hdl.handle.net/20.500.14352/113497
LA eng
NO Burillo, Jesús, et al. «Insulin Resistance and Diabetes Mellitus in Alzheimer’s Disease». Cells, vol. 10, n.o 5, mayo de 2021, p. 1236. DOI.org (Crossref), https://doi.org/10.3390/cells10051236.
NO Ministerio de Ciencia e Innovación
NO Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)
DS Docta Complutense
RD 27 abr 2025