RT Journal Article
T1 Interference impacts working memory in mild cognitive impairment
A1 Aurtenetxe, Sara
A1 Pacios García, Javier
A1 Del Río Grande, David Pedro
A1 López García, María Eugenia
A1 Pineda Pardo, José Ángel
A1 Marcos Dolado, Alberto
A1 Delgado Losada, María Luisa
A1 López Frutos, José María
A1 Maestu Unturbe, Fernando
AB Mild cognitive impairment (MCI) is considered a transitional stage between healthy aging and dementia, specifically Alzheimer's disease (AD). The most common cognitive impairment of MCI includes episodic memory loss and difficulties in working memory (WM). Interference can deplete WM, and an optimal WM performance requires an effective control of attentional resources between the memoranda and the incoming stimuli. Difficulties in handling interference lead to forgetting. However, the interplay between interference and WM in MCI is not well-understood and needs further investigation. The current study investigated the effect of interference during a WM task in 20 MCIs and 20 healthy elder volunteers. Participants performed a delayed match-to-sample paradigm which consisted in two interference conditions, distraction and interruption, and one control condition without any interference. Results evidenced a disproportionate impact of interference on the WM performance of MCIs, mainly in the presence of interruption. These findings demonstrate that interference, and more precisely interruption, is an important proxy for memory-related deficits in MCI. Thus, the current findings reveal novel evidence regarding the causes of WM forgetting in MCI patients, associated with difficulties in the mechanisms of attentional control.
PB Frontiers
YR 2016
FD 2016
LK https://hdl.handle.net/20.500.14352/118912
UL https://hdl.handle.net/20.500.14352/118912
LA eng
NO Aurtenetxe, S., García-Pacios, J., Del Río, D., López, M. E., Pineda-Pardo, J. A., Marcos, A., Delgado Losada, M. L., López-Frutos, J. M., & Maestú, F. (2016). Interference impacts working memory in mild cognitive impairment. Frontiers in Neuroscience, 10. https://doi.org/10.3389/fnins.2016.00443
NO Ministerio de Ciencia e Innovación (España)
NO Ministerio de Economía y Competitividad (España)
NO Gobierno Vasco
DS Docta Complutense
RD 4 abr 2025