RT Journal Article
T1 Beyond Traditional Hyperthermia. In vivo Cancer Treatmentwith Magnetic-Responsive Mesoporous Silica Nanocarriers
A1 Guisasola, Eduardo
A1 Asin, Laura
A1 Beola, Lillianne
A1 De la Fuente, J. M.
A1 Baeza, Alejandro
A1 Vallet Regí, María Dulce Nombre
AB In this study we present an innovation in the tumor treatment in vivo mediated by magnetic mesoporous silica nanoparticles (MMSNs). This device was built with iron oxide magnetic nanoparticles embedded in a mesoporous silica matrix and coated with an engineered thermoresponsive polymer. The magnetic nanoparticles act as internal heating sources under an alternating magnetic field (AMF) that increase the temperature of the surroundings, provoking the polymer transition and consequently the release of a drug trapped inside the silica pores. By a synergic effect between the intracellular hyperthermia and chemotherapy triggered by AMF application, significant tumor growth inhibition was achieved in 48 hours after treatment.Furthermore, the small magnetic loading used in the experiments indicates that the treatment is carried out without a global temperature rise of the tissue, which avoids the problem of the necessity to employ large amounts of magnetic cores, as is common in current magnetic hyperthermia.
PB American Chemical Society
SN 1944-8244
YR 2018
FD 2018-03-21
LK https://hdl.handle.net/20.500.14352/12008
UL https://hdl.handle.net/20.500.14352/12008
LA eng
NO RESEARCHER ID E-8300-2012 (Eduardo Guisasola Cal)ORCID 0000-0002-2549-1745 (Eduardo Guisasola Cal)RESEARCHER ID K-8193-2014 (Alejandro Baeza)ORCID 0000-0002-9042-8865 (Alejandro Baeza)RESEARCHER ID M-3378-2014 (María Vallet Regí)ORCID 0000-0002-6104-4889 (María Vallet Regí)
NO Unión Europea. H2020
NO Ministerio de Economía y Competitividad (MINECO)
DS Docta Complutense
RD 21 mar 2026