RT Journal Article
T1 The influence of dopaminergic polymorphisms on selective stopping
A1 Rincón Pérez, Irene
A1 Echeverry Alzate, Víctor
A1 Sánchez Carmona, Alejandro
A1 Buhler, Kora Mareen Katharina
A1 Hinojosa Poveda, José Antonio
A1 López Moreno, José Antonio
A1 Albert Bitaube, Jacobo
AB Although the genetic influence on global stopping has been extensively investigated, little is known about the genetic contribution to other more complex forms of inhibitory control such as selective stopping. The selectivity of inhibitory control can be assessed by using the stimulus-selective stop-signal task. Notably, recent behavioural and neural evidence indicates that individuals can adopt selective but also non-selective stopping strategies to solve it. This study aimed to investigate for the first time the influence of two relevant dopaminergic polymorphisms (in COMT and DRD2 genes) on stimulus-selective stopping in a sample of 529 adults. Results showed that although none of these polymorphisms (neither individually nor in combination) modulate the latency of the stop process in each strategy (the stop-signal reaction time), the choice of strategy was influenced by their interaction. These results suggest that dopaminergic polymorphisms might influence strategy adoption in selective stopping paradigms, which constitutes a novel finding.
PB Elsevier
SN 0166-4328
YR 2019
FD 2019
LK https://hdl.handle.net/20.500.14352/99424
UL https://hdl.handle.net/20.500.14352/99424
LA eng
NO Rincón-Pérez, I., et al. «The Influence of Dopaminergic Polymorphisms on Selective Stopping». Behavioural Brain Research, vol. 381, marzo de 2020, p. 112441. https://doi.org/10.1016/j.bbr.2019.112441.
NO Ministerio de Ciencia e Innovación (España)
DS Docta Complutense
RD 25 dic 2025