RT Conference Proceedings
T1 Force-extension curves for biomolecules
A1 Carpio Rodríguez, Ana María
A1 Bonilla, Luis L.
A1 Prados, Antonio
AB Single-molecule atomic force spectroscopy probes elastic properties of proteins such as titin and ubiquitin. We analyze bioprotein folding dynamics under both force and length-clamp conditions by modeling polyprotein modules as particles in a bistable potential, connected by harmonic springs. The study of multistable equilibria in these models explains recorded sawtooth force-extension curves. We show that bifurcations and transitions through quasi-stationary domain configurations modified by thermal noise are involved in observed stepwise and abrupt refolding and unfolding phenomena under force-clamp conditions. These predictions agree with experimental observations.
YR 2013
FD 2013-06
LK https://hdl.handle.net/20.500.14352/36189
UL https://hdl.handle.net/20.500.14352/36189
LA eng
DS Docta Complutense
RD 11 abr 2025