RT Conference Proceedings
T1 Force-extension curves for biomolecules
A1 Carpio, Ana
A1 Bonilla, Luis
A1 Prados, Antonio
AB Single-molecule atomic force spectroscopy probes elastic properties of proteins such as titin and ubiquitin. We analyze bioprotein folding dynamics under both force and length-clamp conditions by modeling polyprotein modules as particles in a bistable potential, connected by harmonic springs. The study of multistable equilibria in these models explains recorded sawtooth force-extension curves. We show that bifurcations and transitions through quasi-stationary domain configurations modified by thermal noise are involved in observed stepwise and abrupt refolding and unfolding phenomena under force-clamp conditions. These predictions agree with experimental observations.
YR 2013
FD 2013-06
LK https://hdl.handle.net/20.500.14352/36189
UL https://hdl.handle.net/20.500.14352/36189
LA eng
NO [1] L.L. Bonilla, A. Carpio, A. Prados, Protein unfolding and refolding as transitions through virtual states,   EPL (Europhysics Letters) 108, 28002, 2014[2] A. Prados, A. Carpio, L.L. Bonilla, Sawtooth patterns in force-extension curves of biomolecules: an equilibrium-statistical-mechanics theory,  Physical Review E 88, 012704, 2013[3] A. Prados, A. Carpio, L.L. Bonilla, Spin-oscillator model for the unzipping of biomolecules by mechanical force,  Physical Review E 86, 021919, 2012[4] A. Carpio, LL Bonilla, Wave front depinning transition in discrete one-dimensional reaction-diffusion systems, Physical Review Letters 86, 6034-6037, 2001[5] Effects of disorder on the wave front depinning transition in spatially discrete systems, A. Carpio, L.L. Bonilla, A. Luzon, Physical Review E 65, 035207, 2002[6] A. Carpio, L.L. Bonilla, Depinning transitions in discrete reaction-diffusion equations,  SIAM Journal on Applied Mathematics 63, 1056-1082, 2003[7] A. Carpio, Wave trains, self-oscillations and synchronization in discrete media, Physica D-Nonlinear Phenomena 207, 117-136, 2005
DS Docta Complutense
RD 8 dic 2023