RT Journal Article
T1 Chitosan-Based Composite Membranes with Different Biocompatible Metal Oxide Nanoparticles: Physicochemical Properties and Drug-Release Study
A1 Baroudi, Alia
A1 García Payo, M. Carmen
A1 Khayet Souhaimi, Mohamed
AB Chitosan (CS) composite membranes were prepared using different biocompatible metal oxide nanoparticles (NPs): titanium dioxide (TiO2); iron oxide (Fe3O4); and aluminum oxide (Al2O3). For each nanoparticle, the CS-based composite membranes were prepared with two NPs contents in the CS solution, high (H) and low (L) NPs concentrations. To establish both concentrations, the NPssaturation point in the CS polymeric matrix was determined. The influence of NP concentrations on the physicochemical properties of the CS films was assessed. The prepared CS membranes werecharacterized with different techniques, such as X-ray diffraction (XRD), scanning electron microscopy (SEM), and zeta potential. It was found that the addition of NPs in the CS matrix improved bothswelling and mechanical properties. Nanocomposite CS membranes could be prepared using Al2O3 NPs. Swelling experiments revealed different pH-sensitive mechanisms, which might be beneficialin biomedical applications since solute permeation through CS-based composite membranes could be controlled by adjusting environmental conditions. When aspirin transport (ASA) through theprepared membranes was carried out in different release media, SGF (simulating gastric fluid) and SIF (simulating intestinal fluid without enzymes), it was observed that the Fickian diffusion coefficient(D) was conditioned by the pH of the release solution. In SGIT (simulating gastrointestinal transit) medium, a transition time (ttrans) was detected due to the shrinkage of the CS polymeric chains,and the drug release depended not only on the Fickian’s diffusion but also on the shrinkage of the biopolymer, obeying Peppas and Sahlin equation.
PB MDPI
SN 2073-4360
YR 2023
FD 2023-06-24
LK https://hdl.handle.net/20.500.14352/105215
UL https://hdl.handle.net/20.500.14352/105215
LA eng
NO Baroudi, A.; García-Payo, C.; Khayet, M. Chitosan-Based Composite Membranes with Different Biocompatible Metal Oxide Nanoparticles: Physicochemical Properties and Drug-Release Study. Polymers 2023, 15, 2804. https://doi.org/10.3390/polym15132804
NO 2023 Descuento MDPI
DS Docta Complutense
RD 11 abr 2025