RT Journal Article T1 First Detection of SARS-CoV-2 B.1.617.2 (Delta) Variant of Concern in a Symptomatic Cat in Spain A1 Barroso Arévalo, Sandra A1 Sánchez Morales, Lidia A1 Pérez Sancho, Marta A1 Domínguez Rodríguez, Lucas José A1 Sánchez-Vizcaíno Rodríguez, José Manuel AB Natural and experimental SARS-CoV-2 infection in pets has been widely evidenced since the beginning of the COVID-19 pandemic. Among the numerous affected animals, cats are one of the most susceptible species. However, little is known about viral pathogenicity and transmissibility in the case of variants of concern (VOCs) in animal hosts, such as the B.1.617.2 (Delta) variant first detected in India. Here, we have identified the B.1.617.2 (Delta) VOC in a cat living with a COVID-19 positive owner. The animal presented mild symptoms (sneezing) and a high viral load was detected in the oropharyngeal swab, suggesting that an active infection was occurring in the upper respiratory tract of the cat. Transmission from the owner to the cat occurred despite the human being fully vaccinated against SARS-CoV-2. This study documents the first detection of B.1.165.2 VOC in a cat in Spain and emphasizes the importance of performing active surveillance and genomic investigation on infected animals. PB Frontiers SN 2297-1769 YR 2022 FD 2022-04-01 LK https://hdl.handle.net/20.500.14352/116918 UL https://hdl.handle.net/20.500.14352/116918 LA eng NO Barroso-Arévalo S, Sánchez-Morales L, Pérez-Sancho M, Domínguez L and Sánchez-Vizcaíno JM (2022) First Detection of SARS-CoV-2 B.1.617.2 (Delta) Variant of Concern in a Symptomatic Cat in Spain. Front. Vet. Sci. 9:841430. doi: 10.3389/fvets.2022.841430 NO Author Contributions:SB-A and LS-M performed the sampling, veterinary inspection, and laboratory analysis and wrote the initial manuscript. LD and JS-V acquired the funds. MP-S, LD, and JS-V reviewed the manuscript. All authors have read and approved the final version of the manuscript. NO Instituto de Salud Carlos III DS Docta Complutense RD 10 abr 2025