RT Journal Article
T1 Mesoporous silica nanostructures embedding NIR active plasmonic nanoparticles: Harnessing antimicrobial agents delivery system for photo-assisted eradicating Gram-positive bacteria
A1 Rizzi, Federica
A1 Fanizza, Elisabetta
A1 Giancaspro, Mariangela
A1 Depalo, Nicoletta
A1 Curri, Maria Lucia
A1 González Ortiz, Blanca
A1 Colilla Nieto, Montserrat
A1 Izquierdo Barba, Isabel
A1 Vallet Regí, María Dulce Nombre
AB Implant-associated bone infection is increasingly emerging as a serious threat due to the high demand for orthopedic implants in our ageing society. Bacteria adhering to the surface of implants are highly resistant to conventional antibiotics and increasingly difficult to kill. In the quest for new antimicrobial strategies, multifunctional antimicrobial nanosystems offer new promise in the treatment of such infections. Herein, the development of mesoporous silica-coated plasmonic nanostructures for the delivery of antimicrobial drug for light-assisted therapy for bone infections is reported. Core@shell structures featuring Cu2-xS facet triangular nanoplates (NPL) core and a mesoporous silica shell (Cu2-xS@MSS) were synthesized. Further loading with antimicrobial molecules, such as levofloxacin (Levo) o rifampicin (Rif), allowed to synergistically combine the Cu2-xS NPL inherent antibacterial photoactivity with the pharmacological effects of the drug. The silica-based nanostructures, synthesized using a microemulsion approach, were thoroughly characterized, and their antibacterial activity explored in terms of inhibition of bacteria growth against Staphylococcus aureus. These results outline future applications of these nanoformulations for the management of bone implant-associated bacterial infections.
PB Elsevier
SN 1387-1811
YR 2024
FD 2024-11-15
LK https://hdl.handle.net/20.500.14352/111877
UL https://hdl.handle.net/20.500.14352/111877
LA eng
NO Federica Rizzi, Elisabetta Fanizza, Mariangela Giancaspro, Nicoletta Depalo, Maria Lucia Curri, Blanca González, Montserrat Colilla, Isabel Izquierdo-Barba, María Vallet-Regí, Mesoporous silica nanostructures embedding NIR active plasmonic nanoparticles: Harnessing antimicrobial agents delivery system for photo-assisted eradicating Gram-positive bacteria, Microporous and Mesoporous Materials, Volume 383, 2025, 113414, https://doi.org/10.1016/j.micromeso.2024.113414
DS Docta Complutense
RD 28 abr 2025