RT Journal Article
T1 A novel visible light responsive nanosystem for cancer treatment
A1 Martínez Carmona, Marina
A1 Lozano Borregón, Daniel
A1 Baeza, Alejandro
A1 Colilla Nieto, Montserrat
A1 Vallet Regí, María Dulce Nombre
AB A novel singlet-oxygen sensitive drug delivery nanocarrier able to release their cargo after exposure to visible (Vis) light of a common lamp is presented. This nanodevice is based on mesoporous silica nanoparticles (MSN) decorated with porphyrin-caps grafted via reactive oxygen species (ROS)-cleavable linkages. In presence of Vis light the porphyrinnanocaps produce singlet oxygen molecules that break the sensitive-linker, which triggers pore uncapping and therefore allows the release of the entrapped cargo (topotecan, TOP). This new system takes advantage of thE non-toxicity and greater penetration capacity of Vis radiation and a double antitumor effect due to the drug release and the ROS production. In vitro tests with HOS osteosarcoma cancer cells reveal that TOP is able to be released in a controlled fashion inside the tumor cells. This research work constitutes a proof of concept that opens up promising expectations in the seeking for new alternatives for the treatment of cancer.
PB Royal Society of Chemistry
SN 2040-3372
YR 2017
FD 2017-09-19
LK https://hdl.handle.net/20.500.14352/18195
UL https://hdl.handle.net/20.500.14352/18195
LA eng
NO Unión Europea. H2020
NO Ministerio de Economía y Competitividad (MINECO)
DS Docta Complutense
RD 2 abr 2026