RT Journal Article
T1 Edelfosine (ET-18-OCH3) a Promising Alkylphospholipid against Resistant Trichomonas vaginalis
A1 Ibáñez Escribano, Alexandra
A1 Escario García-Trevijano, José Antonio
A1 Mollinedo García, Faustino
A1 Gómez Barrio, Alicia
AB Edelfosine (ET-18-OCH3) is  an  alkylphospholipid with  an analogous structure  to  miltefosine. Both molecules  are active  against kinetoplastids (Leishmania  spp.,  Trypanosoma  cruzi  and  Trypanosoma brucei). However,  its trichomonacidal effect has never  been studied.  For  this purpose, edelfosine  has been evaluated  in vitro  for its ability to  inhibit  proliferation of  the common sexually transmitted parasite  Trichomonas vaginalis  following  a standardized  fluorimetric procedure.  The results show an IC50  = 19.8  µM  against  metronidazole-sensitive  isolates and  a remarkable IC50  =  7.6 µM  against  the metronidazole-resistant IR78. This enhanced  effect  against the resistant isolate suggests  another possible mode of  action in  comparison  with the reference drug.  Moreover,  T.  vaginalis  exhibits  a different  growth rate  due  to the metabolic  modifications  according to  its resistant trait.  These  results are  in  consonance with the trichomonacidal effect  observed by  other authors using the  analog miltefosine  against  resistant  samples, provoking membrane alterations and apoptosis. It is estimated that  2.5–10%  of  clinical cases of  trichomonosis  are  produced  by  resistant  isolates.  The  absence  of pharmacological alternatives to the unique two  5-nitroimidazole  drugs  approved by the FDA makes necessary the incorporation of novel trichomonacidal  drugs with  a  different mode of  action. Taken together, our  results,  in consonance  with  previous  reports,  suggest  the promising  use  of  these alkylphospholipids  as  an  alternative trichomonacidal  drug  against  resistant  cases.
PB MDPI
SN 2504-3900
YR 2017
FD 2017-10-19
LK https://hdl.handle.net/20.500.14352/19276
UL https://hdl.handle.net/20.500.14352/19276
LA eng
NO Ibáñez Escribano, A., Escario García-Trevijano, J. A., Mollinedo García, F. et al. «Edelfosine (ET-18-OCH3) a Promising Alkylphospholipid against Resistant Trichomonas Vaginalis». Proceedings of the 1st Molecules Medicinal Chemistry Symposium, Barcelona, Spain, MDPI, 2017, p. 653. DOI.org (Crossref), https://doi.org/10.3390/proceedings1060653.
NO Ministerio de Economía, Comercio y Empresa (España)
DS Docta Complutense
RD 26 abr 2025