RT Journal Article
T1 Milk fat globule membrane-enriched milk improves episodic memory: A randomized, parallel, double-blind, placebo-controlled trial in older adults
A1 Calvo, María V.
A1 Loria Kohen, Viviana Constanza
A1 Díaz-Mardomingo, Carmen
A1 García-Herranz, Sara
A1 Baliyan, Shishir
A1 Tomé-Carneiro, João
A1 Colmenarejo, Gonzalo
A1 Visioli, Francesco
A1 Venero, César
A1 Fontecha, Javier
A2 Elsevier, 
AB Cognitive decline is one of the most important consequences of aging and pharmacological  therapies had been largely unsuccessful. Other strategies include the use of functional foods  to reduce the burden of cognitive decline. The MFGM is an important source of polar lipids  and glycoproteins that decline in the aging brain. We have developed a milk drink fortified  with MFGM (MFGM-M) as a dietary supplement and studied it in a randomized clinical pilot  study. Forty-four > 65-year-old healthy or mildly cognitively impaired subjects received  MFGM-M or control milk (CM) for 14 weeks, during which they underwent a battery of  cognitive tests. Lipidomic analyzes were also performed. The female participants showed  improvement in episodic memory, the ability to recall events in our lives. It is conceivable  that any intervention should be started before clinical symptoms manifest, as a preventive  measure against cognitive decline. Future long-term studies may shed further light on this  point.
PB Elsevier
SN 1756-4646
YR 2023
FD 2023-11-08
LK https://hdl.handle.net/20.500.14352/103785
UL https://hdl.handle.net/20.500.14352/103785
LA eng
NO María V. Calvo, Viviana Loria Kohen, Carmen Díaz-Mardomingo, Sara García-Herranz, Shishir Baliyan, João Tomé-Carneiro, Gonzalo Colmenarejo, Francesco Visioli, César Venero, Javier Fontecha, Milk fat globule membrane-enriched milk improves episodic memory: A randomized, parallel, double-blind, placebo-controlled trial in older adults, Journal of Functional Foods, 2023,105849,https://doi.org/10.1016/j.jff.2023.105849.
NO Ministerio de Ciencia, Innovación y Universidades
DS Docta Complutense
RD 8 abr 2025