RT Journal Article
T1 The enzymatic sphingomyelin to ceramide conversion increases the shear membrane viscosity at the air-water interface
A1 Catapano, Elisa R.
A1 Natale, Paolo
A1 Monroy Muñoz, Francisco
A1 López-Montero, Iván
AB Whereas most of lipids have viscous properties and they do not have significant elastic features, ceramides behave as very rigid solid assemblies, displaying viscoelastic behaviour at physiological temperatures. The present review addresses the surface rheology of lipid binary mixtures made of sphingomyelin and ceramide. However, ceramide is formed by the enzymatic cleavage of sphingomyelin in cell plasma membranes. The consequences of the enzymatically-driven ceramide formation involve mechanical alterations of the embedding membrane. Here, an increase on surface shear viscosity was evidenced upon enzymatic incubation of sphingomyelin monolayers. The overall rheological data are discussed in terms of the current knowledge of the thermotropic behaviour of ceramide-containing model membranes.
PB Elsevier
SN 0001-8686
YR 2017
FD 2017
LK https://hdl.handle.net/20.500.14352/19027
UL https://hdl.handle.net/20.500.14352/19027
LA eng
NO The research leading to these results has received funding from the European Research Council under the European Union's Seventh Framework Programme (ERC grant agreement n° 338133)
NO Unión Europea. FP7
NO Ministerio de Economía y Competitividad (MINECO)
DS Docta Complutense
RD 7 may 2024