RT Journal Article
T1 In Vivo Near-Infrared Imaging Using Ternary Selenide Semiconductor Nanoparticles with an Uncommon Crystal Structure
A1 Yao, Jingke
A1 Lifante, José
A1 Rodríguez Sevilla, Paloma
A1 Fuente Fernández, María de la
A1 Sanz Rodríguez, Francisco
A1 Ortgies, Dirk H.
A1 Gómez Calderón, Óscar
A1 Melle Hernández, Sonia
A1 Ximendes, Erving
A1 Jaque García, Daniel
A1 Marin, Riccardo
AB The implementation of in vivo fluorescence imaging as a reliable diagnostic imaging modality at the clinical level is still far from reality. Plenty of work remains ahead to provide medical practitioners with solid proof of the potential advantages of this imaging technique. To do so, one of the key objectives is to better the optical performance of dedicated contrast agents, thus improving the resolution and penetration depth achievable. This direction is followed here and the use of a novel AgInSe2 nanoparticle-based contrast agent (nanocapsule) is reported for fluorescence imaging. The use of an Ag2Se seeds-mediated synthesis method allows stabilizing an uncommon orthorhombic crystal structure, which endows the material with emission in the second biological window (1000–1400 nm), where deeper penetration in tissues is achieved. The nanocapsules, obtained via phospholipid-assisted encapsulation of the AgInSe2 nanoparticles, comply with the mandatory requisites for an imaging contrast agent—colloidal stability and negligible toxicity—and show superior brightness compared with widely used Ag2S nanoparticles. Imaging experiments point to the great potential of the novel AgInSe2-based nanocapsules for high-resolution, whole-body in vivo imaging. Their extended permanence time within blood vessels make them especially suitable for prolonged imaging of the cardiovascular system.
PB Wiley
SN 1613-6810
YR 2021
FD 2021-09-23
LK https://hdl.handle.net/20.500.14352/4468
UL https://hdl.handle.net/20.500.14352/4468
LA eng
NO Received: June 16, 2021 / First published: 23 September 2021.
NO Unión Europea. Horizonte 2020
NO Ministerio de Ciencia e Innovación (MICINN)
NO Ministerio de Ciencia e Innovación (MICINN)/FEDER
NO Instituto de Salud Carlos III (ISCIII)
NO Comunidad de Madrid
NO Fundación para la Investigación Biomédica del Hospital Universitario Ramón y Cajal
NO China Scholarship Council
NO Becas de formación Juan de la Cierva (España)
DS Docta Complutense
RD 12 abr 2025