RT Journal Article
T1 Proinflammatory cytokine profile differences between primary open angle and pseudoexfoliative glaucoma
A1 Vidal Villegas, Beatriz
A1 Burgos Blasco, Bárbara
A1 Santiago Álvarez, Jose Luis
A1 Espino Paisán, Laura
A1 Fernández Vigo, José Ignacio
A1 Andrés Guerrero, Vanesa
A1 García Feijoo, Julián
A1 Martínez De La Casa Fernández-Borrella, José María
AB Introduction: Few studies have investigated glaucoma biomarkers in aqueous humor and tear and have found elevations of proinflammatory cytokines in patients with primary open-angle glaucoma (POAG) and pseudoexfoliative glaucoma (PXG). In this study we investigate differences in inflammatory cytokines between POAG and PXG patients to find specific disease biomarkers.Methods: For this purpose, tear and aqueous humor samples of 14 eyes with POAG and 15 eyes with PXG undergoing cataract surgery were immunoassayed for 27 pro-inflammatory cytokines. The concentrations of cytokines in tear and aqueous humor and their association with clinical variables were analysed, correlated and compared between the groups.  Results: We found that the levels of three cytokines differed significantly in the aqueous humor of POAG and PXG patients: IL-12 and IL-13 were higher in the POAG group, while MCP-1(MCAF) was higher in the PXG group. The number of topical hypotensive medications was correlated with diminished levels of two cytokines (IL-7 and basic fibroblast growth factor) in aqueous humor in the POAG group and with diminished levels of IL-12 in tear in the PXG group.Conclusion:  We conclude that both POAG and PXG show elevated concentrations of proinflammatory cytokines in tear and aqueous humor that could be used as biomarkers for these types of glaucoma and that the concentrations in aqueous humor of three cytokines: IL-12, IL-13 and MCP-1(MCAF) could be used to differentiate POAG and PXG.
PB Karger Publishers
SN 0030-3747
YR 2021
FD 2021-10-18
LK https://hdl.handle.net/20.500.14352/4447
UL https://hdl.handle.net/20.500.14352/4447
LA eng
NO Vidal Villegas, B., Burgos Blasco, B., Santiago Álvarez, J. L. et al. «Proinflammatory Cytokine Profile Differences between Primary Open-Angle and Pseudoexfoliative Glaucoma». Ophthalmic Research, vol. 65, n.o 1, 2022, pp. 111-20. DOI.org (Crossref), https://doi.org/10.1159/000519816.
NO Vidal Villegas, B., Burgos Blasco, B., Santiago Álvarez, J. L. et al. «Proinflammatory Cytokine Profile Differences between Primary Open-Angle and Pseudoexfoliative Glaucoma». Ophthalmic Research, vol. 65, n.o 1, 2022, pp. 111-20. DOI.org (Crossref), https://doi.org/10.1159/000519816.
NO Instituto de Salud Carlos III/Fondo Europeo de Desarrollo Regional
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 30 sept 2024