RT Journal Article
T1 Characterization of Retinal Drusen in Subjects at High Genetic Risk of Developing Sporadic Alzheimer’s Disease: An Exploratory Analysis
A1 López Cuenca, Inés
A1 García Martín, Elena Salobrar
A1 Gil Salgado, Inés
A1 Sánchez Puebla, Lídia
A1 Elvira Hurtado, Lorena
A1 Fernández Albarral, José Antonio
A1 Ramírez Toraño, Federico
A1 Barabash, Ana
A1 Frutos Lucas, Jaisalmer de
A1 Salazar Corral, Juan José
A1 Ramirez Sebastian, Jose Manuel
A1 Ramírez Sebastián, Ana Isabel
A1 Hoz Montañana, María Rosa de
AB Having a family history (FH+) of Alzheimer’s disease (AD) and being a carrier of at least one ɛ4 allele of the ApoE gene are two of the main risk factors for the development of AD. AD and age-related macular degeneration (AMD) share one of the main risk factors, such as age, and characteristics including the presence of deposits (Aβ plaques in AD and drusen in AMD); however, the role of apolipoprotein E isoforms in both pathologies is controversial. We analyzed and characterized retinal drusen by optical coherence tomography (OCT) in subjects, classifying them by their AD FH (FH- or FH+) and their allelic characterization of ApoE ɛ4 (ApoE ɛ4- or ApoE ɛ4+) and considering cardiovascular risk factors (hypercholesterolemia, hypertension, and diabetes mellitus). In addition, we analyzed the choroidal thickness by OCT and the area of the foveal avascular zone with OCTA. We did not find a relationship between a family history of AD or any of the ApoE isoforms and the presence or absence of drusen. Subjects with drusen show choroidal thinning compared to patients without drusen, and thinning could trigger changes in choroidal perfusion that may give rise to the deposits that generate drusen
PB MDPI
SN 2075-4426
YR 2022
FD 2022-05-23
LK https://hdl.handle.net/20.500.14352/71694
UL https://hdl.handle.net/20.500.14352/71694
LA eng
NO Received: 19 April 2022 / Revised: 17 May 2022 / Accepted: 19 May 2022 / Published: 23 May 2022
NO Ministerio de Ciencia e Innovación (MICINN)
NO Instituto de Salud Carlos III (ISCIII)
NO Ministerio de Economía y Competitividad (MINECO)
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 17 jul 2024