RT Journal Article
T1 Autoantibodies in cancer: a systematic review of their clinical role in the most prevalent cancers
A1 Montero Calle, Ana
A1 Garranzo Asensio, María
A1 Moreno Casbas, Maria Teresa
A1 Campuzano Ruiz, Susana
A1 Barderas Manchado, Rodrigo
AB Although blood autoantibodies were initially associated with autoimmune diseases, multiple evidence have been accumulated showing their presence in many types of cancer. This has opened their use in clinics, since cancer autoantibodies might be useful for early detection, prognosis, and monitoring of cancer patients. In this review, we discuss the different techniques available for their discovery and validation. Additionally, we discuss here in detail those autoantibody panels verified in at least two different reports that should be more likely to be specific of each of the four most incident cancers. We also report the recent developed kits for breast and lung cancer detection mostly based on autoantibodies and the identification of novel therapeutic targets because of the screening of the cancer humoral immune response. Finally, we discuss unsolved issues that still need to be addressed for the implementation of cancer autoantibodies in clinical routine for cancer diagnosis, prognosis, and/or monitoring.
PB Frontiers Media S.A.
YR 2024
FD 2024-08-21
LK https://hdl.handle.net/20.500.14352/123956
UL https://hdl.handle.net/20.500.14352/123956
LA eng
NO Montero-Calle A, Garranzo-Asensio M, Moreno-Casbas MT, Campuzano S and Barderas R (2024) Autoantibodies in cancer: a systematic review of their clinical role in the most prevalent cancers. Front. Immunol. 15:1455602. doi: 10.3389/fimmu.2024.1455602
NO AES-ISCIII
NO MCIN/AEI/10.13039/ 501100011033
NO ERDF A way of making Europe
NO European Innovation Council (EIC)
DS Docta Complutense
RD 1 ene 2026