RT Journal Article
T1 Bactericidal ZnO glass-filled thermoplastic polyurethane and polydimethyl siloxane composites to inhibit biofilm-associated infections
A1 Cabal, Belén
A1 Sevillano Fernández, David
A1 Fernández García, Elisa
A1 Alou Cervera, Luis
A1 Suárez, Marta
A1 González Hidalgo, Natalia
A1 Moya, José S.
A1 Torrecillas, Ramón
AB This study investigates a novel approach to controlling biofilms of the most frequent pathogens implicated in the etiology of biomaterials-associated infections. New bactericidal filler based on a non-toxic glass, belonging to B2O3-SiO2-Al2O3-Na2O-ZnO system, was used to formulate composites of the most widely used polymers in biomedical applications [i.e. thermoplastic polyurethane (TPU) and polydimethyl siloxane (PDMS)], with varying percentage by weight of the bactericidal glass (5, 15, 25, 35, 50%). Glass-filled polymer composites show dramatically restricted bacterial colonisation and biofilm formation. They exhibit time- and dose-dependent killing, with maximal action at 5 days. The highest activity was found against S.epidermidis biofilm (99% of reduction), one of the most common cause of nosocomial infections. The tensile properties of the obtained glass-filled composites are comparable with the literature data concerning polymeric biomaterials for medical implants and devices. In addition, all the materials presented in this research, revealed an excellent biocompatibility. This was disclosed by cell viability values above 70%, none alteration on erythrocyte membrane or cell functionality in contact with materials (haemolytic index 0–2%), and absence of interferences in blood coagulation (intrinsic, extrinsic and final pathways).
PB Springer Nature
YR 2019
FD 2019-02-26
LK https://hdl.handle.net/20.500.14352/105975
UL https://hdl.handle.net/20.500.14352/105975
LA eng
NO Cabal B, Sevillano D, Fernández-García E, Alou L, Suárez M, González N, Moya JS, Torrecillas R. Bactericidal ZnO glass-filled thermoplastic polyurethane and polydimethyl siloxane composites to inhibit biofilm-associated infections. Sci Rep. 2019 Feb 26;9(1):2762.
DS Docta Complutense
RD 29 sept 2024